{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:02:37Z","timestamp":1777417357112,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,3]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report development of a seizure after administration of ropivacaine.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY:<\/jats:title>\n A 26-year-old woman was scheduled for a cesarean section because of a stagnation of the uterine neck dilatation after 4.5 hours. After peridural administration of 279 mg of ropivacaine (total dose) over five hours, she presented with oculogyric movements and slurred speech that preceded convulsions of the face and of the upper limbs.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n Convulsions are well-known complications of local anesthetics. Ropivacaine, a relatively new agent, is considered safer for the central nervous system. Currently, there are only four published reports that implicate ropivacaine as being associated with convulsions. The likelihood that ropivacaine caused the seizure in our patient was possible based on the Naranjo probability scale.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Clinicians should be aware of the possibility of seizures as an adverse effect of ropivacaine.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.10200","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T17:09:48Z","timestamp":1054660188000},"page":"311-313","source":"Crossref","is-referenced-by-count":16,"title":["Seizure Induced by Ropivacaine"],"prefix":"10.1177","volume":"35","author":[{"given":"Doroth\u00e9e Y","family":"Bisschop","sequence":"first","affiliation":[{"name":"Doroth\u00e9e Y Bisschop PharmD, Clinical Pharmacist, Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Maison Blanche, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Alardo","sequence":"additional","affiliation":[{"name":"Jean-Pierre Alardo MD, Physician, Service d'Anesth\u00e9sie R\u00e9animation, Centre Hospitalier, Troyes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brahim","family":"Razgallah","sequence":"additional","affiliation":[{"name":"Brahim Razgallah MD, Physician, Service d'Anesth\u00e9sie R\u00e9animation, Centre Hospitalier"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard Y","family":"Just","sequence":"additional","affiliation":[{"name":"Bernard Y Just MD, Head of Anesthesic Department, Service d'Anesth\u00e9sie R\u00e9animation, Centre Hospitalier"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure Y","family":"Germain","sequence":"additional","affiliation":[{"name":"Marie-Laure Y Germain PharmD, Clinical Pharmacist, Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Maison Blanche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9 G","family":"Millart","sequence":"additional","affiliation":[{"name":"Herv\u00e9 G Millart MD PhD, Professor, Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Maison Blanche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry C","family":"Trenque","sequence":"additional","affiliation":[{"name":"Thierry C Trenque MD PhD, Director of Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Maison Blanche"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"bibr1-aph.10200","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.507"},{"key":"bibr2-aph.10200","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198911000-00003"},{"key":"bibr3-aph.10200","volume-title":"Naropeine (ropivacaine injection)","year":"1999"},{"key":"bibr4-aph.10200","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199906000-00040"},{"key":"bibr5-aph.10200","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9802600214"},{"key":"bibr6-aph.10200","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199711000-00031"},{"key":"bibr7-aph.10200","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/80.6.843"},{"key":"bibr8-aph.10200","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198912000-00008"},{"key":"bibr9-aph.10200","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936010-00005"},{"key":"bibr10-aph.10200","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05347.x"},{"key":"bibr11-aph.10200","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:34Z","timestamp":1777374274000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.10200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["10.1345\/aph.10200"],"URL":"https:\/\/doi.org\/10.1345\/aph.10200","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]}}}