{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:05:38Z","timestamp":1777417538285,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of multiple episodes of seizure activity in an AIDS patient following amphotericin B infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time. The patient's concurrent medications included didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazine. Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotericin B administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>AIDS and cryptococcal meningitis, both of which the patient had, can potentially cause seizures. The patient had a history of alcohol abuse; alcohol intake as well as withdrawal can also cause seizures. Didanosine also has a potential for inducing seizures. However, these other potential causes of seizure were ruled out. The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Amphotericin B seems to be the probable cause of the seizures. To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.10260","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T17:10:28Z","timestamp":1054660228000},"page":"1037-1041","source":"Crossref","is-referenced-by-count":3,"title":["Amphotericin B\u2014Induced Seizures in a Patient with AIDS"],"prefix":"10.1177","volume":"35","author":[{"given":"Augustine S","family":"Aruna","sequence":"first","affiliation":[{"name":"Augustine S Aruna PharmD FASCP, Associate Professor of Clinical Pharmacy, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA; Clinical Pharmacy Consultant, Veterans Affairs Medical Center, New Orleans"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shatha A","family":"AL-Samarrai","sequence":"additional","affiliation":[{"name":"Shatha A AL-Samarrai PharmD, Clinical Pharmacy Intern, College of Pharmacy, Xavier University of Louisiana, Veterans Affairs Medical Center, New Orleans"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah S","family":"AL-Humaidan","sequence":"additional","affiliation":[{"name":"Abdullah S AL-Humaidan PharmD MPH, Fellow of Pharmacokinetics and Critical Care (Neurology), College of Pharmacy, University of Louisiana at Monroe, Monroe, LA; Medical Center of Louisiana\/LSU Health Science Center, Department of Neurology, New Orleans; and Clinical Pharmacist, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"bibr-bibr1-aph.10260","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70523-X"},{"key":"bibr-bibr2-aph.10260","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.Supplement_2.S507"},{"key":"bibr-bibr3-aph.10260","doi-asserted-by":"publisher","DOI":"10.1128\/br.37.3.166-196.1973"},{"key":"bibr-bibr4-aph.10260","first-page":"579","volume":"56","author":"Gold W","year":"1955","journal-title":"Antibiot Annu"},{"key":"bibr-bibr5-aph.10260","first-page":"218","volume":"14","author":"Fernandez Martinez EM","year":"1999","journal-title":"Neurologia"},{"key":"bibr-bibr6-aph.10260","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370103"},{"key":"bibr-bibr7-aph.10260","volume-title":"AHFS drug information 2001","year":"2001"},{"key":"bibr-bibr8-aph.10260","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1967.tb03815.x"},{"key":"bibr-bibr9-aph.10260","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.Supplement_5.S522"},{"key":"bibr-bibr10-aph.10260","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90443-0"},{"key":"bibr-bibr11-aph.10260","unstructured":"Kale PB, Pau AK. 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