{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:31:52Z","timestamp":1789381912042,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of toxic epidermal necrolysis (TEN) associated with trimethoprim\/sulfamethoxazole (TMP\/SMX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 34-year-old Asian woman developed a severe, desquamating mucocutaneous reaction (TEN) after six days of taking TMP\/SMX to treat a presumed urinary tract infection (UTI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>TMP\/SMX is often recommended as first-line therapy for UTIs, sinusitis, bronchitis, and as prophylaxis and treatment for Pneumocystis carinii pneumonia. TEN is a rare, but severe condition associated with sulfonamide use. This article describes a typical case and offers an opportunity for review of this potentially serious reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Sulfonamides are often implicated in the majority of drug-induced cases of TEN. This case report illustrates the typical presentation of sulfonamide-induced TEN with a prodrome, characteristic rash, mucous membrane lesions, and systemic involvement. Practitioners should be aware of this rare adverse effect and closely observe patients for cutaneous manifestations or complaints. Any suspected drug should be discontinued if clinical evaluation leads to the suspicion of Stevens\u2014Johnson syndrome or TEN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.10310","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T17:10:20Z","timestamp":1054660220000},"page":"694-697","source":"Crossref","is-referenced-by-count":24,"title":["Trimethoprim\/Sulfamethoxazole\u2014Induced Toxic Epidermal Necrolysis"],"prefix":"10.1177","volume":"35","author":[{"given":"Sharon","family":"See","sequence":"first","affiliation":[{"name":"Sharon See PharmD, Assistant Clinical Professor, St. John's University College of Pharmacy and Allied Health Professions, Jamaica, NY; Clinical Coordinator, Department of Family Medicine, Beth Israel Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Mumford","sequence":"additional","affiliation":[{"name":"James M Mumford MD, Associate Residency Director for Inpatient Training, Beth Israel Residency in Urban Family Practice, Department of Family Medicine, Beth Israel Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"bibr1-aph.10310","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"bibr2-aph.10310","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70196-0"},{"key":"bibr3-aph.10310","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00816.x"},{"key":"bibr4-aph.10310","first-page":"644","volume-title":"Fitzpatrick's dermatology in general medicine","volume":"1","author":"Fritsch PO","year":"1999","edition":"5"},{"key":"bibr5-aph.10310","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(98)00011-X"},{"key":"bibr6-aph.10310","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(93)90156-7"},{"key":"bibr7-aph.10310","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"bibr8-aph.10310","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.3.323"},{"key":"bibr9-aph.10310","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11369-1"},{"key":"bibr10-aph.10310","doi-asserted-by":"publisher","DOI":"10.2340\/0001555571171172"},{"key":"bibr11-aph.10310","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00185.x"},{"key":"bibr12-aph.10310","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198611000-00001"},{"key":"bibr13-aph.10310","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332404"},{"key":"bibr14-aph.10310","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330077013"},{"key":"bibr15-aph.10310","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90252-K"},{"key":"bibr16-aph.10310","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90706-X"},{"key":"bibr17-aph.10310","first-page":"125","volume":"40","author":"Arora VK","year":"1998","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"bibr18-aph.10310","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr19-aph.10310","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604043341414"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:49Z","timestamp":1777374289000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.10310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":19,"aliases":["10.1345\/1542-6270(2001)035<0694:tsiten>2.0.co;2"],"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1345\/aph.10310"],"URL":"https:\/\/doi.org\/10.1345\/aph.10310","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}