{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:22Z","timestamp":1791308662821,"version":"4.3.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,6]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating illness caused by the JC virus, a polyomavirus that occurs in 4\u20135% of HIV-positive patients. Mortality is high, and no useful therapy has been identified. Highly active antiretroviral therapy (HAART) has been reported to be effective in halting progression of the disease in some, but not all, patients. Cidofovir has been shown to be active against polyomaviruses.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n To review data on the use of cidofovir to treat PML.<\/jats:p>\n <\/jats:sec>\n \n DATA SOURCES:<\/jats:title>\n English-language case reports and clinical studies were located through a literature search (MEDLINE and AIDSLINE, 1995\u2013July 2000).<\/jats:p>\n <\/jats:sec>\n \n STUDY SELECTION AND DATA EXTRACTION:<\/jats:title>\n Relevant case reports and studies describing the use of cidofovir for PML were reviewed.<\/jats:p>\n <\/jats:sec>\n \n DATA SYNTHESIS:<\/jats:title>\n Most case reports describing the use of cidofovir have shown that the drug is effective in the treatment of PML. Some patients were also receiving HAART concurrently; therefore, it is not clear which treatment modality had a greater impact on PML. However, cidofovir may be effective in patients whose disease has progressed despite HAART or who are unable to tolerate these regimens. A pilot study of cidofovir for treating PML has completed enrollment, but preliminary results showed no benefit.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Cidofovir may be the most reasonable treatment option for PML in HIV-infected individuals who fail to improve with HAART or who are unable to tolerate these regimens. Patients who receive cidofovir should be monitored for renal and ocular toxicity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.10338","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T17:10:20Z","timestamp":1054660220000},"page":"741-744","source":"Crossref","is-referenced-by-count":28,"title":["Use of Cidofovir in Progressive Multifocal Leukoencephalopathy"],"prefix":"10.1177","volume":"35","author":[{"given":"Marisel","family":"Segarra-Newnham","sequence":"first","affiliation":[{"name":"Marisel Segarra-Newnham PharmD BCPS, Clinical Pharmacy Specialist, Infectious Diseases, Veterans Affairs Medical Center, West Palm Beach, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M","family":"Vodolo","sequence":"additional","affiliation":[{"name":"Kristen M Vodolo PharmD Student, College of Pharmacy, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"bibr1-aph.10338","first-page":"1400","volume-title":"Principles and practice of infectious diseases","author":"Demeter LM","year":"1995","edition":"4"},{"key":"bibr2-aph.10338","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.4.891"},{"key":"bibr3-aph.10338","doi-asserted-by":"publisher","DOI":"10.1086\/315087"},{"key":"bibr4-aph.10338","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.5.1305"},{"key":"bibr5-aph.10338","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-12-199512150-00006"},{"key":"bibr6-aph.10338","doi-asserted-by":"publisher","DOI":"10.1159\/000008046"},{"key":"bibr7-aph.10338","doi-asserted-by":"publisher","DOI":"10.1086\/515153"},{"key":"bibr8-aph.10338","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040837"},{"key":"bibr9-aph.10338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199702273360914"},{"key":"bibr10-aph.10338","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199910010-00010"},{"key":"bibr11-aph.10338","doi-asserted-by":"publisher","DOI":"10.1086\/514762"},{"key":"bibr12-aph.10338","first-page":"1526","volume":"11","author":"Baqi M","year":"1997","journal-title":"AIDS"},{"key":"bibr13-aph.10338","doi-asserted-by":"publisher","DOI":"10.1086\/313574"},{"key":"bibr14-aph.10338","first-page":"533","volume":"12","author":"Sadler M","year":"1998","journal-title":"AIDS"},{"key":"bibr15-aph.10338","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(90)92324-E"},{"key":"bibr16-aph.10338","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92504-U"},{"key":"bibr17-aph.10338","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91376-J"},{"key":"bibr18-aph.10338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805073381903"},{"key":"bibr19-aph.10338","unstructured":"National Library of Medicine. Safety and efficacy of topotecan HCl to treat HIV-infected patients with AIDS-related progressive multifocal leukoencephalopathy (PML) [cited 2000 Dec 29]. Available from URL: http:\/\/www.clinicaltrials.gov."},{"key":"bibr20-aph.10338","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.587"},{"key":"bibr21-aph.10338","first-page":"361","volume":"4","author":"Oliviera AC","year":"1998","journal-title":"J Neurovirol"},{"key":"bibr22-aph.10338","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050440"},{"key":"bibr23-aph.10338","doi-asserted-by":"publisher","DOI":"10.1086\/517060"},{"key":"bibr24-aph.10338","volume-title":"Vistide (cidofovir)","year":"1999"},{"key":"bibr25-aph.10338","unstructured":"National Library of Medicine. A pilot study of the effect of cidofovir for the treatment of progressive multifocal leukoencephalopathy (PML) in subjects with acquired immunodeficiency syndrome (AIDS) [cited 2000 Dec 29]. Available from URL: http:\/\/www.clinicaltrials.gov."},{"key":"bibr26-aph.10338","unstructured":"Marra CM, Rajicic N, Barker DE, Cohen B, Clifford D, and the ACTG 363 Team. Prospective pilot study of cidofovir for HIV-associated progressive multifocal leukoencephalopathy (PML). In: Proceedings of the 8th Conference on Retroviruses and Opportunistic Infections. Chicago, IL, February 4\u20138, 2001."}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:49Z","timestamp":1777374289000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.10338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":26,"aliases":["10.1345\/1542-6270(2001)035<0741:uocipm>2.0.co;2"],"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1345\/aph.10338"],"URL":"https:\/\/doi.org\/10.1345\/aph.10338","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}