{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:38Z","timestamp":1777417238044,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,11]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To review data describing use of intermittent dosing of alendronate.<\/jats:p>\n <\/jats:sec>\n \n DATA SOURCES:<\/jats:title>\n A comprehensive literature search was conducted using MEDLINE (1966\u2013May 2001) and EMBASE (1974\u2013May 2001) databases to identify all information regarding intermittent dosing of alendronate.<\/jats:p>\n <\/jats:sec>\n \n DATA SYNTHESIS:<\/jats:title>\n A small number of clinical studies have evaluated the use of intermittent alendronate dosing in an attempt to improve patient compliance and adverse events.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Evidence from more controlled clinical trials and postmarketing data are needed to demonstrate the therapeutic efficacy and tolerability of intermittent alendronate dosing. 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