{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:15:42Z","timestamp":1777418142688,"version":"3.51.4"},"reference-count":93,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1998,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To review recent developments in the pharmacotherapy of obesity, including the agents currently approved for use in the management of obesity and those under development.<\/jats:p>\n <\/jats:sec>\n \n DATA SOURCES<\/jats:title>\n A MEDLINE search from January 1990 to July 1997 was conducted to identify English literature available on the pharmacotherapy of obesity. The search was supplemented by a review of the bibliographies of identified literature.<\/jats:p>\n <\/jats:sec>\n \n STUDY SELECTION<\/jats:title>\n All controlled and uncontrolled trials were reviewed. When available, double-blind, placebo-controlled trials were used preferentially.<\/jats:p>\n <\/jats:sec>\n \n DATA EXTRACTION<\/jats:title>\n Agents were reviewed with regard to mechanism of action, clinical trial data regarding efficacy, adverse effects, pharmacokinetics, drug interactions, and contraindications where information was available. Study design, selected population, results, and adverse effect information were included.<\/jats:p>\n <\/jats:sec>\n \n DATA SYNTHESIS:<\/jats:title>\n The anorexiants currently available or under development for the management of obesity regulate food intake and satiety via the adrenergic and\/or serotonergic pathways. Clinical trials have shown a 10\u201315% weight loss can typically be anticipated; however, little long-term safety and efficacy data are available. Adverse events tend to be mild and self-limiting, but serious adverse events can occur. Treatment options under development include thermogenic agents, digestive inhibitors, and analogs and antagonists of hormones that regulate food intake and satiety.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Several mechanisms to control weight are currently under investigation for the management of obesity. Since obesity is a chronic condition, further studies should be conducted to evaluate the long-term safety and efficacy of these agents and the role of combination therapy using different modalities.<\/jats:p>\n <\/jats:sec>\n \n OBJETIVO<\/jats:title>\n Revisar los recientes avances farmacol\u00f3gicos en el tratamiento de la obesidad, incluyendo aquellos medicamentos actualmente aprobados para este uso y otros que todav\u00eda se encuentran en desarrollo.<\/jats:p>\n <\/jats:sec>\n \n FUENTES DE INFORMACION<\/jats:title>\n Se realiz\u00f3 una b\u00fasqueda computarizada de MEDLINE para determinar art\u00edculos publicados en la literatura inglesa entre enero de 1990 a julio de 1997. Adem\u00e1s, se utilizar\u00f3n las referencias citadas en los art\u00edculos identificados en la b\u00fasqueda.<\/jats:p>\n <\/jats:sec>\n \n SELECCION DE ESTUDIOS<\/jats:title>\n Estudios cl\u00ednicos de tipo controlados y no-controlados fueron incluidos en el an\u00e1lisis. Se le di\u00f3 preferencia a aquellos estudios cl\u00ednicos que eran de dise\u00f1o doble ciego, controlados, y que usaron un grupo control de placebo.<\/jats:p>\n <\/jats:sec>\n \n EXTRACCI\u00d3N DE DATOS<\/jats:title>\n Los medicamentos fueron evaluados de acuerdo al mecanismo de acci\u00f3n farmacol\u00f3gica, la informaci\u00f3n ci\u00e9ntifica relacionada con su eficacia, efectos secundarios, farmacocin\u00e9tica, interacciones de medicamentos, y contraindicaciones de uso. El disefio ci\u00e9ntifico utilizado en los estudios cl\u00ednicos, el grupo de pacientes incluido en los estudios, los resultados obtenidos, y los efectos adversos fueron adem\u00e1s incluidos en el an\u00e1lisis.<\/jats:p>\n <\/jats:sec>\n \n SINTESIS<\/jats:title>\n Los medicamentos anor\u00e9xicos actualmente disponibles para el tratamiento de la obesidad regulan la cantidad de alimentos ingeridos y la sensaci\u00f3n de saciedad atrav\u00e9s de los mecanismos adren\u00e9rgicos y de serotonina. Los estudios cl\u00ednicos disponibles han demostrado que usualmente se puede esperar de un 10\u201315% de perdida de peso con el uso de estos medicamentos. Sin embargo, no existe mucha informaci\u00f3n relacionada al uso seguro y la eficacia de estos medicamentos a largo plazo. Los efectos adversos observados con estos medicamentos tienden a ser leves y de corta duraci\u00f3n, pero efectos adversos severos pueden ocurrir. Otras opciones de tratamiento incluyen medicamentos termog\u00e9nicos, inhibidores digestivos, y an\u00e1logos y antagonistas de diferentes hormonas que regulan la ingesti\u00f3n de alimentos y la sensaci\u00f3n de saciedad.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONES<\/jats:title>\n Actualmente, algunos de los mecanismos relacionados con el control de peso est\u00e1n siendo investigados para poder determinar futuros tratamientos de la obesidad. Debido a que la obesidad es un problema cr\u00f3nico, se tienen que realizar estudios cl\u00ednicos adicionales disefiados para evaluar la eficacia y el uso seguro de estos medicamentos a largo plazo. Adem\u00e1s, el uso de estos medicamentos en combinaci\u00f3n tiene que ser evaluado.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIF<\/jats:title>\n R\u00e9viser les d\u00e9veloppements dans la pharmacoth\u00e9rapie de l'ob\u00e9sit\u00e9 ainsi que les m\u00e9dicaments actuellement utilis\u00e9s et ceux qui sont en d\u00e9veloppement.<\/jats:p>\n <\/jats:sec>\n \n REVUE DE LITT\u00c9RATURE<\/jats:title>\n Une recherche sur MEDLINE a \u00e9t\u00e9 entreprise pour identifier les publications en langue anglaise concernant le traitement de l'ob\u00e9sit\u00e9 et publi\u00e9es entre janvier 1990 \u00e0 juillet 1997. Les bibliographies des r\u00e9f\u00e9rences pertinentes ont aussi \u00e9t\u00e9 scrut\u00e9es.<\/jats:p>\n <\/jats:sec>\n \n S\u00c9LECTION DES \u00c9TUDES<\/jats:title>\n Toutes les \u00e9tudes, contr\u00f4l\u00e9es ou non, ont \u00e9t\u00e9 r\u00e9vis\u00e9es. Cependant, les \u00e9tudes \u00e0 double insu ou contr\u00f4l\u00e9es par placebo ont \u00e9t\u00e9 pr\u00e9f\u00e9r\u00e9es.<\/jats:p>\n <\/jats:sec>\n \n EXTRACTION DE L'INFORMATION:<\/jats:title>\n Chaque m\u00e9dicament a \u00e9t\u00e9 r\u00e9vis\u00e9 pour le m\u00e9canisme d'action, les donn\u00e9es d'efficacit\u00e9 clinique, les r\u00e9actions ind\u00e9sirables, la pharmacocin\u00e9tique, les interactions m\u00e9dicamenteuses, et les contre-indications. Le devis des \u00e9tudes, la population \u00e0 l'\u00e9tude, les r\u00e9sultats, et les r\u00e9actions ind\u00e9sirables sont pr\u00e9sentes.<\/jats:p>\n <\/jats:sec>\n \n R\u00c9SUM\u00c9<\/jats:title>\n Les anorexig\u00e8nes disponibles sur le march\u00e9 contr\u00f4lent l'apport alimentaire et la sati\u00e9t\u00e9 par une action sur les voies adr\u00e9nergiques et s\u00e9rotoninergiques. Les \u00e9tudes cliniques ont d\u00e9montr\u00e9 qu'une perte de poids de 10\u201315% est un objectif r\u00e9aliste. Cependant, peu d'\u00e9tudes d'efficacit\u00e9 et de s\u00e9curit\u00e9 \u00e0 long terme sont disponibles. Les r\u00e9actions ind\u00e9sirables sont g\u00e9n\u00e9ralement mineures et se r\u00e9solvent spontan\u00e9ment. Cependant, des r\u00e9actions s\u00e9v\u00e8res peuvent aussi survenir. De nouvelles avenues th\u00e9rapeutiques sont en d\u00e9veloppement. Elles comportent des agents thermog\u00e9niques, des inhibiteurs de la digestion, des analogues et antagonistes hormonaux qui r\u00e9gissent l'apport alimentaire et la sati\u00e9t\u00e9.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Plusieurs strat\u00e9gies de contr\u00f4le de l'ob\u00e9sit\u00e9 sont actuellement en investigation. Puisque l'ob\u00e9sit\u00e9 est une maladie chronique, des \u00e9tudes devraient \u00eatre r\u00e9alis\u00e9es pour \u00e9valuer l'efficacit\u00e9 et la s\u00e9curit\u00e9 des m\u00e9dicaments ainsi que le r\u00f4le des th\u00e9rapies combin\u00e9es.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.17039","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"88-102","source":"Crossref","is-referenced-by-count":18,"title":["Update on the Pharmacotherapy of Obesity"],"prefix":"10.1177","volume":"32","author":[{"given":"Jennifer","family":"Cerulli","sequence":"first","affiliation":[{"name":"Jennifer Cerulli PharmD BCPS, Fellow, Nutrition Support, Division of Pharmacy Practice, Albany College of Pharmacy, Albany, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben M","family":"Lomaestro","sequence":"additional","affiliation":[{"name":"Ben M Lomaestro PharmD, Clinical Pharmacist, Pharmacy 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