{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T08:38:02Z","timestamp":1786869482372,"version":"build-2736575974"},"reference-count":8,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a suspected case of isoniazid-induced psychosis in a 31-year-old woman.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 31-year-old white woman without a prior psychiatric history presented with psychotic symptoms suspected to be related to prophylactic treatment with isoniazid after she tested positive to a tuberculin (purified protein derivative) test. The psychotic symptoms resolved partially after isoniazid was discontinued and completely after treatment with olanzapine was begun. The patient remained symptom-free 11 months after discharge from the hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Cases of isoniazid-related psychiatric disorders reported in the literature include psychosis, obsessive\u2013compulsive neurosis, and mania. With the increasing prevalence of tuberculosis in the US, more people are expected to receive treatment for tuberculosis. Pyridoxine deficiency may play a role in the pathogenesis of isoniazid-induced psychosis. Such deficiency states may be detected indirectly by measuring urinary metabolites of tryptophan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Clinicians should be aware of this adverse effect of isoniazid and that it may present with a broad clinical picture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.17377","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"889-891","source":"Crossref","is-referenced-by-count":44,"title":["Isoniazid-Induced Psychosis"],"prefix":"10.1177","volume":"32","author":[{"given":"Adekola O","family":"Alao","sequence":"first","affiliation":[{"name":"Adekola O Alao MD MRCPsych, Resident in Psychiatry, Department of Psychiatry, State University of New York Health Science Center, Syracuse, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C","family":"Yolles","sequence":"additional","affiliation":[{"name":"Jennifer C Yolles MD, Attending Psychiatrist, Assistant Professor, Department of Psychiatry, State University of New York Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,9,1]]},"reference":[{"key":"bibr1-aph.17377","first-page":"1004","volume-title":"Harrison's principles of internal medicine","author":"Raviglione MC","year":"1998","edition":"14"},{"key":"bibr2-aph.17377","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402801131"},{"key":"bibr3-aph.17377","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700205"},{"key":"bibr4-aph.17377","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/161.11.707"},{"key":"bibr5-aph.17377","first-page":"387","volume":"51","author":"Bhatia MS","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"bibr6-aph.17377","doi-asserted-by":"publisher","DOI":"10.1177\/070674378803300729"},{"key":"bibr7-aph.17377","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(68)90163-9"},{"key":"bibr8-aph.17377","first-page":"1555","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Marcus R","year":"1995","edition":"9"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.17377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.17377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:35Z","timestamp":1777374455000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.17377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["10.1345\/aph.17377"],"URL":"https:\/\/doi.org\/10.1345\/aph.17377","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}