{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:16:47Z","timestamp":1777418207917,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report successful desensitization in a patient with a history of end-stage renal disease (ESRD) and anaphylactic shock after receiving vancomycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 47-year-old white woman with a history of ESRD was admitted to the hospital reporting persistent nausea, vomiting, and diffuse abdominal pain. She had developed anaphylactic shock after exposure to vancomycin 3 years prior to this hospitalization. The patient's hospital course was complicated by septic shock and positive blood cultures for methicillin-resistant Staphylococcus epidermidis. The patient tolerated vancomycin desensitization and received intravenous vancomycin 100 mg\/d for 21 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>The desensitization protocol used in this report allows for gradual increases in vancomycin serum concentrations, avoiding peak and trough concentrations that occur with intravenous boluses. Maintaining the desensitized state is dependent on the continuous presence of the antigen with a return of clinical sensitivity after drug discontinuation. The vancomycin desensitization protocol and subsequent dosing strategy was used to ensure the continuous presence of vancomycin at steady-state concentrations to prevent the return of anaphylactic sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Desensitization was successful in a patient with ESRD and history of anaphylactic shock to vancomycin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.17411","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"1020-1023","source":"Crossref","is-referenced-by-count":10,"title":["Successful Vancomycin Desensitization in a Patient with End-Stage Renal Disease and Anaphylactic Shock to Vancomycin"],"prefix":"10.1177","volume":"32","author":[{"given":"Suellyn J","family":"Sorensen","sequence":"first","affiliation":[{"name":"Suellyn J Sorensen PharmD BCPS, Clinical Pharmacist, Infectious Diseases, Indiana University Hospital of Clarian Health; Assistant Professor of Pharmacy Practice, Butler University College of Pharmacy and Health Sciences, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L","family":"Wise","sequence":"additional","affiliation":[{"name":"Steven L Wise MD, Assistant Clinical Professor of Medicine, Allergy and Immunology, Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaffar A","family":"Al-Tawfiq","sequence":"additional","affiliation":[{"name":"Jaffar A Al-Tawfiq MBBS, Infectious Diseases Fellow, Division of Infectious Diseases, Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon L","family":"Robb","sequence":"additional","affiliation":[{"name":"Jon L Robb PharmD, at time of writing, PharmD Student, Butler University College of Pharmacy and Health Sciences; now, Clinical Pharmacist, St. Mary's Medical Center, Evansville, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert E","family":"Cushing","sequence":"additional","affiliation":[{"name":"Herbert E Cushing MD, Assistant Professor of Medicine, Division of Infectious Diseases, Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"bibr1-aph.17411","first-page":"402","volume":"73","author":"Anne' S","year":"1994","journal-title":"Ann Allergy"},{"key":"bibr2-aph.17411","doi-asserted-by":"publisher","DOI":"10.3109\/00365549209061350"},{"key":"bibr3-aph.17411","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-1-157_1"},{"key":"bibr4-aph.17411","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a55251"},{"key":"bibr5-aph.17411","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390210145031"},{"key":"bibr6-aph.17411","first-page":"215","volume":"58","author":"Jamieson DM","year":"1987","journal-title":"Ann Allergy"},{"key":"bibr7-aph.17411","first-page":"1726","volume-title":"Allergy, principles and practice","author":"Sullivan TJ","year":"1993","edition":"4"},{"key":"bibr8-aph.17411","first-page":"395","volume-title":"Allergic diseases diagnosis and management","author":"Deswarte RD","year":"1993","edition":"4"},{"key":"bibr9-aph.17411","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90635-3"},{"key":"bibr10-aph.17411","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(87)90365-4"},{"key":"bibr11-aph.17411","first-page":"375","volume":"73","author":"Sullivan TJ","year":"1994","journal-title":"Ann Allergy"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.17411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.17411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:42Z","timestamp":1777374402000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.17411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1345\/aph.17411"],"URL":"https:\/\/doi.org\/10.1345\/aph.17411","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}