{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:18:55Z","timestamp":1777418335092,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1998,12]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report a case of successful desensitization to dapsone for Pneumocystis carinii pneumonia (PCP) prophylaxis in a patient unable to tolerate trimethoprim\/sulfamethoxazole (TMP\/SMX) desensitization or dapsone at standard doses.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY:<\/jats:title>\n A 37-year-old HIV-positive African-American man was treated for pneumonia with TMP\/SMX and then continued on the drug for PCP prophylaxis. After experiencing a pruritic maculopapular rash with TMP\/SMX, both at standard doses and after attempting a desensitization regimen to the drug, he was started on dapsone for PCP prophylaxis. He experienced a rash and fever after taking dapsone at standard PCP prophylactic doses. At this time, an 18-day oral dapsone rechallenge by dose escalation was attempted, and it was well tolerated.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n This case suggests that utilization of a dapsone desensitization regimen may permit a viable treatment option in patients previously thought to be intolerant to the agent. More regimens of this type should be attempted and the results published, using both dapsone and TMP\/SMX, so that standard desensitization treatment guidelines may eventually be adopted.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.17441","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"1302-1305","source":"Crossref","is-referenced-by-count":7,"title":["Successful Desensitization to Dapsone for\n Pneumocystis Carinii<\/i>\n Prophylaxis in an HIV-Positive Patient"],"prefix":"10.1177","volume":"32","author":[{"given":"Donna E","family":"Cook","sequence":"first","affiliation":[{"name":"Donna E Cook PharmD, at time of writing, PharmD Student, Department of Pharmacy Practice, University of Washington School of Pharmacy, Seattle, WA; now, Assistant Professor of Pharmacy Practice, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce L","family":"Kossey","sequence":"additional","affiliation":[{"name":"Joyce L Kossey PharmD, Clinical Patient Care Pharmacist, Specialized Prescription Services, Inc., Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,12,1]]},"reference":[{"key":"bibr1-aph.17441","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282007"},{"key":"bibr2-aph.17441","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261601"},{"key":"bibr3-aph.17441","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-11-199406010-00006"},{"key":"bibr4-aph.17441","first-page":"177","volume":"62","author":"White MV","year":"1989","journal-title":"Ann Allergy"},{"key":"bibr5-aph.17441","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90667-2"},{"key":"bibr6-aph.17441","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1981.01650010044023"},{"key":"bibr7-aph.17441","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199411000-00018"},{"key":"bibr8-aph.17441","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360170071011"},{"key":"bibr9-aph.17441","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199301000-00010"},{"key":"bibr10-aph.17441","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199509030-00001"},{"key":"bibr11-aph.17441","first-page":"1","volume":"41","author":"Centers for Disease Control and Prevention","year":"1992","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr12-aph.17441","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/54.13.1545"},{"key":"bibr13-aph.17441","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199717020-00004"},{"key":"bibr14-aph.17441","first-page":"448","volume":"9","author":"O'Kane EB","year":"1996","journal-title":"JABFP"},{"key":"bibr15-aph.17441","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60037-3"},{"key":"bibr16-aph.17441","first-page":"20","volume":"3","author":"Hardy WD","year":"1995","journal-title":"Improving the management of HIV disease: a publication of the International AIDS Society \u2014 USA"},{"key":"bibr17-aph.17441","doi-asserted-by":"publisher","DOI":"10.1001\/jama.267.4.512"},{"key":"bibr18-aph.17441","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00008-3"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.17441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.17441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:56Z","timestamp":1777374416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.17441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["10.1345\/aph.17441"],"URL":"https:\/\/doi.org\/10.1345\/aph.17441","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}