{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:20:09Z","timestamp":1790385609244,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of acute interstitial nephritis (AIN) related to administration of vancomycin for the treatment of Staphylococcus aureus sternal wound infection, osteomyelitis, and infective endocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>Reports in the literature regarding vancomycin-induced AIN are scarce. We describe the fifth known case of AIN, in a 64-year-old white man who developed fever, maculopapular rash, acute renal failure, eosinophilia, and eosinophiluria after approximately 1 month of vancomycin treatment. The results of the renal biopsy were consistent with an allergic drug reaction. Four months after his initial episode of AIN, the patient was rechallenged with vancomycin for the treatment of S. aureus septic arthritis. One day after initiation of vancomycin, serum eosinophils started to rise, his urine tested positive for eosinophils, but his serum creatinine remained stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our case report and others from the literature suggest vancomycin causes allergic AIN. Clinicians should be aware of this adverse effect in an era of increasing use of vancomycin for treatment of resistant gram-positive organisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.17448","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"1160-1164","source":"Crossref","is-referenced-by-count":48,"title":["Vancomycin-Induced Acute Interstitial Nephritis"],"prefix":"10.1177","volume":"32","author":[{"given":"Amy O","family":"Wai","sequence":"first","affiliation":[{"name":"Amy O Wai BSc(Pharm), Clinical Instructor, Faculty of Pharmaceutical Sciences, University of British Columbia, and Clinical Pharmacist, Home Intravenous Antibiotic Program, Clinical Service Unit (CSU) Pharmaceutical Sciences, Vancouver General Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes MS","family":"Lo","sequence":"additional","affiliation":[{"name":"Agnes MS Lo BSc(Pharm), PharmD Student, Faculty of Pharmaceutical Sciences, University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Abdo","sequence":"additional","affiliation":[{"name":"Ayman Abdo MD, Medical Resident, Faculty of Medicine, University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawziah","family":"Marra","sequence":"additional","affiliation":[{"name":"Fawziah Marra BSc(Pharm) PharmD, Assistant Professor, Faculty of Pharmaceutical Sciences, University of British Columbia, and Pharmacotherapeutic Specialist, Infectious Diseases, CSU Pharmaceutical Sciences, Vancouver General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"bibr1-aph.17448","first-page":"417","volume":"2","author":"Cunha 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