{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:20:18Z","timestamp":1787239218701,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of pill-induced esophagitis caused by oral rifampin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>English-language references identified via a MEDLINE search from January 1966 to May 1998 and a bibliographic review of pertinent articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>A large number of oral medications have been reported to cause pill-induced esophagitis. This case represents the second report attributed to rifampin. A 70-year-old white man receiving vancomycin, gentamicin, and oral rifampin for treatment of Staphylococcus epidermidis prosthetic valve endocarditis reported dysphagia immediately after swallowing a rifampin capsule on the fourth day of therapy. The following day, fiberoptic laryngoscopy and esophagoscopy demonstrated a red capsule partially embedded in the neopharynx. A day later, upper esophageal obstruction consistent with edema related to pill-induced esophagitis was identified by barium swallow. Following the procedure, the patient was placed on total parenteral nutrition and took nothing by mouth. Sixteen days after first reporting dysphagia, he was placed on a full liquid diet. Several factors may have increased the patient's risk for pill-induced esophagitis, including age, bedridden state, gastroesophageal reflux disease, simultaneous administration of several medications, and neopharyngeal stricture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Oral rifampin may cause esophagitis. Healthcare providers should be alert to the possibility of pill-induced esophagitis in susceptible patients. Patients with predisposing factors for the development of pill-induced esophagitis should be educated about proper swallowing of oral medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.18116","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"27-31","source":"Crossref","is-referenced-by-count":22,"title":["Pill-Induced Esophagitis Caused by Oral Rifampin"],"prefix":"10.1177","volume":"33","author":[{"given":"Steve J","family":"Smith","sequence":"first","affiliation":[{"name":"Steve J Smith PharmD, at time of writing, PharmD Student, School of Pharmacy, University of the Pacific, Stockton, CA; now, with Wal-Mart"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey J","family":"Lee","sequence":"additional","affiliation":[{"name":"Audrey J Lee PharmD BCPS, Internal Medicine Clinical Pharmacist, Pharmacy Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA; Assistant Professor of Pharmacy Practice, School of Pharmacy, University of the Pacific"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S","family":"Maddix","sequence":"additional","affiliation":[{"name":"Daniel S Maddix PharmD, Infectious Diseases and Drug Information Pharmacist, Pharmacy Service, San Francisco Veterans Affairs Medical Center; Adjunct Faculty, School of Pharmacy, University of the Pacific; Assistant Clinical Professor of Pharmacy, School of Pharmacy, University of California, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert W","family":"Chow","sequence":"additional","affiliation":[{"name":"Albert W Chow MD, Fellow, Facial Plastic and Reconstructive Surgery, Plastic and Reconstructive Surgery, Section Plastic and Reconstructive Surgery, Department of Surgery, University of Louisville, Louisville, KY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"bibr1-aph.18116","first-page":"542","volume-title":"Current medical diagnosis and treatment 1997","author":"McQuaid KR","year":"1997","edition":"36"},{"key":"bibr2-aph.18116","first-page":"519","volume-title":"Gastrointestinal and liver disease \u2014 Pathophysiology, diagnosis, management","author":"Baehr PH","year":"1998","edition":"6"},{"key":"bibr3-aph.18116","first-page":"2258","volume-title":"Otolaryngology \u2014 Head and neck surgery","author":"Singer J","year":"1993","edition":"2"},{"key":"bibr4-aph.18116","first-page":"1135","volume":"32","author":"Yee J","year":"1994","journal-title":"Radiol Clin North Am"},{"key":"bibr5-aph.18116","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(21)00591-4"},{"key":"bibr6-aph.18116","first-page":"758","volume":"82","author":"Bott S","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"bibr7-aph.18116","first-page":"489","volume-title":"Gastroenterology","author":"Spiegelman GA","year":"1995"},{"key":"bibr8-aph.18116","doi-asserted-by":"publisher","DOI":"10.1007\/BF02266997"},{"key":"bibr9-aph.18116","first-page":"618","volume":"81","author":"Chen CY","year":"1982","journal-title":"J Formos Med Assoc"},{"key":"bibr10-aph.18116","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90431-C"},{"key":"bibr11-aph.18116","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91158-2"},{"key":"bibr12-aph.18116","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6356.1717"},{"key":"bibr13-aph.18116","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1986.tb02922.x"},{"key":"bibr14-aph.18116","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.10.1363"},{"key":"bibr15-aph.18116","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002400601"},{"key":"bibr16-aph.18116","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900317"},{"key":"bibr17-aph.18116","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610033351403"},{"key":"bibr18-aph.18116","first-page":"1322","volume":"92","author":"Graham DY","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"bibr19-aph.18116","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-2-133"},{"key":"bibr20-aph.18116","first-page":"1044","volume":"91","author":"Yamaoka K","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"bibr21-aph.18116","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296821"},{"key":"bibr22-aph.18116","first-page":"527","volume":"35","author":"Goihman-Yahr M","year":"1996","journal-title":"Int J Dermatol"},{"key":"bibr23-aph.18116","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70185-8"},{"key":"bibr24-aph.18116","unstructured":"McEvoy GK, ed. 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