{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:48:03Z","timestamp":1777416483103,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1999,6]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report a case of possible amphotericin B\u2013induced hepatotoxicity in a patient with pulmonary blastomycosis.<\/jats:p>\n <\/jats:sec>\n \n SUMMARY:<\/jats:title>\n A 26-year-old white man with life-threatening pulmonary blastomycosis developed elevation of his liver enzymes after the addition of amphotericin B to his initial itraconazole therapy. The hepatotoxicity resolved rapidly with discontinuation of the amphotericin B, and the blastomycosis was successfully treated with itraconazole alone.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n This case illustrates an unusual occurrence of hepatotoxicity associated with a short course of amphotericin B. Liver biopsy was compatible with drug-induced changes and showed no evidence of blastomycosis. Discontinuation of amphotericin B with no other therapeutic changes resulted in a rapid resolution of hepatotoxicity. A possible adverse drug interaction with itraconazole and amphotericin B is postulated based on the mechanism of action of each drug.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Amphotericin B therapy can be associated with many adverse effects, but reports of hepatotoxicity are rare. Closer monitoring of liver enzymes in patients receiving amphotericin B, especially in combination with potentially hepatotoxic agents, including azole antifungal drugs, would be prudent.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.18181","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"683-685","source":"Crossref","is-referenced-by-count":18,"title":["Hepatotoxicity Possibly Caused by Amphotericin B"],"prefix":"10.1177","volume":"33","author":[{"given":"John","family":"Gill","sequence":"first","affiliation":[{"name":"John Gill MD, Resident, Program in Internal Medicine, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry R","family":"Sprenger","sequence":"additional","affiliation":[{"name":"Henry R Sprenger BScPharm, Staff Pharmacist, London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D","family":"Ralph","sequence":"additional","affiliation":[{"name":"Edward D Ralph MD FRCPC, Professor, Department of Internal Medicine, University of Western Ontario, London Health Sciences Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Michael D Sharpe MD FRCPC, Associate Professor, Department of Anaesthesia, Program in Critical Care Medicine, University of Western Ontario, London Health Sciences Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"bibr1-aph.18181","first-page":"1245","volume":"131","author":"Miller MA","year":"1984","journal-title":"Can Med Assoc J"},{"key":"bibr2-aph.18181","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-53-5-1027"},{"key":"bibr3-aph.18181","volume-title":"Product monograph. 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