{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:25:13Z","timestamp":1777418713526,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To describe a case of rhabdomyolysis in a cadaveric renal transplant (CRT) patient receiving atorvastatin and cyclosporine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 40-year-old Asian woman with a history of systemic lupus erythematosus (SLE) presented with bilateral lower-extremity weakness and elevated concentrations of creatine kinase (CK), aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and alkaline phosphatase after two months of concomitant therapy with atorvastatin and cyclosporine. Her other medications were not known to cause rhabdomyolysis; neither was there evidence of an SLE flare. After atorvastatin was discontinued, her CK concentrations declined dramatically and her symptoms resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Rhabdomyolysis has been reported in patients treated with other 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors when used in combination with cyclosporine. Atorvastatin, a relatively new HMG-CoA reductase inhibitor, has not been reported to cause rhabdomyolysis when used concomitantly with cyclosporine. However, its pharmacologic and pharmacokinetic properties make an interaction with cyclosporine possible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Similar to other members of the HMG-CoA reductase inhibitor class, atorvastatin may interact with cyclosporine and potentially result in rhabdomyolysis. Clinicians should be aware of this possible drug interaction and carefully monitor patients receiving these two drugs concomitantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.19039","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:08:19Z","timestamp":1079024899000},"page":"1176-1179","source":"Crossref","is-referenced-by-count":81,"title":["Rhabdomyolysis Associated with Concomitant Use of Atorvastatin and Cyclosporine"],"prefix":"10.1177","volume":"33","author":[{"given":"Helene C","family":"Maltz","sequence":"first","affiliation":[{"name":"Helene C Maltz BSPharm, PharmD Student, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise L","family":"Balog","sequence":"additional","affiliation":[{"name":"Denise L Balog PharmD, Assistant Clinical Professor of Pharmacy, College of Pharmacy and Allied Health Professions, St. John's University; Clinical Coordinator, Adult Internal Medicine, Department of Pharmacy K-04, New York Presbyterian Hospital, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhoong S","family":"Cheigh","sequence":"additional","affiliation":[{"name":"Jhoong S Cheigh MD, Professor of Clinical Medicine, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"bibr1-aph.19039","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00965-X"},{"key":"bibr2-aph.19039","first-page":"349","volume":"47","author":"Hunninghake D","year":"1998","journal-title":"J Fam Pract"},{"key":"bibr3-aph.19039","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199702150-00001"},{"key":"bibr4-aph.19039","first-page":"246","volume":"33","author":"Li PK","year":"1995","journal-title":"Int J Clin Pharmacol Ther"},{"key":"bibr5-aph.19039","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502900911"},{"key":"bibr6-aph.19039","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199201000-00018"},{"key":"bibr7-aph.19039","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509073331003"},{"key":"bibr8-aph.19039","first-page":"1130","volume":"23","author":"Ensley RD","year":"1991","journal-title":"Transplant Proc"},{"key":"bibr9-aph.19039","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199605270-00010"},{"key":"bibr10-aph.19039","doi-asserted-by":"publisher","DOI":"10.1177\/106002809703100417"},{"key":"bibr11-aph.19039","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(05)80029-3"},{"key":"bibr12-aph.19039","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8931"},{"key":"bibr13-aph.19039","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1993.tb03948.x"},{"key":"bibr14-aph.19039","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(97)00014-9"},{"key":"bibr15-aph.19039","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(05)80028-1"},{"key":"bibr16-aph.19039","doi-asserted-by":"publisher","DOI":"10.1177\/106002809603001204"},{"key":"bibr17-aph.19039","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199612150-00005"},{"key":"bibr18-aph.19039","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180111"},{"key":"bibr19-aph.19039","volume-title":"Product information: Lipitor (atorvastatin)","year":"1996"},{"key":"bibr20-aph.19039","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753050-00011"},{"key":"bibr21-aph.19039","first-page":"2753","volume":"57","author":"Petri M","year":"1998","journal-title":"Am Fam Physician"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:55Z","timestamp":1777374475000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.19039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["10.1345\/aph.19039"],"URL":"https:\/\/doi.org\/10.1345\/aph.19039","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}