{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T12:35:06Z","timestamp":1782045306123,"version":"3.54.5"},"reference-count":13,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2000,7]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report a case of tablet impaction of nifedipine extended-release tablets (Procardia XL) discovered one year after discontinuation of the drug in a patient with peptic stricture.<\/jats:p>\n <\/jats:sec>\n \n DATA SOURCES:<\/jats:title>\n English-language references identified via a MEDLINE search from 1966 through September 1998 and bibliographic review of pertinent articles.<\/jats:p>\n <\/jats:sec>\n \n DATA SYNTHESIS:<\/jats:title>\n Extended-release nifedipine has been associated with the formation of medication bezoars in case reports. Bezoars are concretions of undigested material within the gastrointestinal (GI) tract. Although they can occur throughout the GI tract, bezoars are most frequently located in the stomach and, rarely, in the duodenum. We report an unusual case of tablet impaction with a gastric outlet obstruction in the duodenal area discovered one year after the patient stopped taking extended-release nifedipine.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Extended-release nifedipine is associated with tablet impaction, even long after discontinuing administration. Although rare, clinicians should be aware of this potential problem when prescribing extended-release medications to patients at risk, and should consider this possible etiology when refractory epigastric pain and weight loss occur.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.19112","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T16:38:38Z","timestamp":1054658318000},"page":"862-864","source":"Crossref","is-referenced-by-count":22,"title":["Extended-Release Nifedipine Bezoar Identified One Year after Discontinuation"],"prefix":"10.1177","volume":"34","author":[{"given":"Lisa M","family":"Niezabitowski","sequence":"first","affiliation":[{"name":"Lisa M Niezabitowski, at time of writing, PharmD Student, College of Pharmacy, University of Florida, Gainesville, FL; now, PharmD Administrative Resident\/Fellow, University of Wisconsin Hospital & Clinics, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie Nhu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Billie Nhu Nguyen PharmD, at time of writing, Clinical Fellow in Pharmacy Practice and Family Medicine, College of Pharmacy, University of Florida; now, Clinical Assistant Professor, Department of Phar macy Practice, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Gums","sequence":"additional","affiliation":[{"name":"John G Gums PharmD, Professor, Department of Pharmacy Practice and Family Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"bibr1-aph.19112","first-page":"758","volume-title":"Gastrointestinal disease: pathophysiology, diagnosis, management","author":"Salena BJ","year":"1993"},{"key":"bibr2-aph.19112","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17420"},{"key":"bibr3-aph.19112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb01088.x"},{"key":"bibr4-aph.19112","doi-asserted-by":"publisher","DOI":"10.1007\/s002619900029"},{"key":"bibr5-aph.19112","first-page":"2224","volume":"90","author":"Georgopoulos S","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"bibr6-aph.19112","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.4.8.715"},{"key":"bibr7-aph.19112","doi-asserted-by":"publisher","DOI":"10.1159\/000171515"},{"key":"bibr8-aph.19112","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199410000-00020"},{"key":"bibr9-aph.19112","first-page":"849","volume":"12","author":"Shepherd MF","year":"1993","journal-title":"Clin Pharm"},{"key":"bibr10-aph.19112","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400160160038"},{"key":"bibr11-aph.19112","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400090140025"},{"key":"bibr12-aph.19112","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90630-9"},{"key":"bibr13-aph.19112","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:03:33Z","timestamp":1777374213000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.19112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":13,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1345\/aph.19112"],"URL":"https:\/\/doi.org\/10.1345\/aph.19112","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}