{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:27:10Z","timestamp":1792405630999,"version":"4.4.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To obtain and evaluate evidence about the supposed disulfiram-like interaction between metronidazole and ethanol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>MEDLINE search from January 1964 to June 1999, using the terms metronidazole, ethanol, and drug reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>The manufacturer's warnings include a disulfiram-like reaction between metronidazole and ethanol. However, review of reports published between 1969 and 1982 produced no convincing evidence that this reaction exists. Six case reports involving eight patients were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Four of the eight cases were serious, including one death, but the authors of all the reports presumed the metronidazole\u2013ethanol reaction to be an established pharmacologic fact. None provided evidence that could justify their conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.19118","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T16:37:26Z","timestamp":1054658246000},"page":"255-257","source":"Crossref","is-referenced-by-count":37,"title":["Do Ethanol and Metronidazole Interact to Produce a Disulfiram-Like Reaction?"],"prefix":"10.1177","volume":"34","author":[{"given":"Caroline S","family":"Williams","sequence":"first","affiliation":[{"name":"Caroline S Williams BPharm, Senior Clinical Pharmacist, Pharmacy Department, Winchester and Eastleigh NHS Trust, Winchester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R","family":"Woodcock","sequence":"additional","affiliation":[{"name":"Kevin R Woodcock MBBS MSc MRCP, Consultant Physician, Department of Sexual Health, Winchester and Eastleigh NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"bibr1-aph.19118","volume-title":"Flagyl. 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