{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:56:59Z","timestamp":1777417019067,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of severe neutropenia developing in association with riluzole 200 mg\/d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 63-year-old woman with amyotrophic lateral sclerosis (ALS) presented with nausea, anorexia, and fever two weeks following inadvertent dose escalation of riluzole from 100 to 200 mg\/d. Granulocytopenia was diagnosed and evaluation for a possible causative infectious process was negative; riluzole was considered a possible offender. Blood counts returned to normal with discontinuation of riluzole and administration of filgramstim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Riluzole is a glutamate release inhibitor used in the treatment of ALS, a devastating, progressive neurodegenerative disorder affecting motor neurons. A variety of adverse effects have been described with riluzole therapy, most commonly dizziness and gastrointestinal disorders. In this patient, multiple investigations failed to reveal an infectious cause or other drug-induced cause for the granulocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Granulocytopenia has been reported as an adverse effect of riluzole but is not a complication well known to clinicians, and there are no detailed reports published in the literature. In this patient, several lines of evidence raise the possibility of a causal relationship between riluzole and granulocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.19153","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T16:37:47Z","timestamp":1054658267000},"page":"322-324","source":"Crossref","is-referenced-by-count":9,"title":["Reversible Granulocytopenia in Association with Riluzole Therapy"],"prefix":"10.1177","volume":"34","author":[{"given":"Will A","family":"North","sequence":"first","affiliation":[{"name":"Will A North MD, Assistant Professor, Department of Neurology, University of Connecticut Health Center, Farmington, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir M","family":"Khan","sequence":"additional","affiliation":[{"name":"Amir M Khan MD, at time of writing, Fellow, Division of Hematology-Oncology, University of Connecticut Health Center; now, Assistant Professor, King Faisal University-Dammam Campus, Dammam, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold T","family":"Yamase","sequence":"additional","affiliation":[{"name":"Harold T Yamase MD, Associate Professor, Department of Pathology, University of Connecticut Health Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R","family":"Sporn","sequence":"additional","affiliation":[{"name":"Jonathan R Sporn MD, Associate Professor, Division of Hematology-Oncology, University of Connecticut Health Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"bibr1-aph.19153","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1983.tb04810.x"},{"key":"bibr2-aph.19153","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.511"},{"key":"bibr3-aph.19153","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"bibr4-aph.19153","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300901"},{"key":"bibr5-aph.19153","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91680-3"},{"key":"bibr6-aph.19153","first-page":"807","volume-title":"Hematology","author":"Dale DC","year":"1990","edition":"5"},{"key":"bibr7-aph.19153","doi-asserted-by":"publisher","DOI":"10.1177\/106002809703100614"},{"key":"bibr8-aph.19153","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr9-aph.19153","first-page":"483","volume":"39","author":"Albertini RS","year":"1978","journal-title":"J Clin Psychiatry"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:03:08Z","timestamp":1777374188000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.19153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1345\/aph.19153"],"URL":"https:\/\/doi.org\/10.1345\/aph.19153","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}