{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:32Z","timestamp":1777417112214,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>\n                      To characterize the effects of anthropometric and pharmacotherapeutic variables on acute emesis induced by cisplatin-containing regimens with dosages \u00b750 mg\u00b7m\n                      <jats:sup>\u22122<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A prospective, cross-sectional, noncontrolled study was performed to analyze acute vomiting during the first 24 hours in patients treated in a Spanish hospital. The patients received an intravenous combination of drugs (2 doses of metoclopramide 3 mg\/kg, dexamethasone 20 mg) as first-choice antiemetic therapy. Intravenous ondansetron 8 mg and dexamethasone 20 mg served as an alternative regimen in patients &lt;30 years old with a history of extrapyramidal manifestations or emesis in previous cycles. Therapeutic failure was used as a dependent variable, defined as three or more vomiting episodes documented by the patients. Other variables were the chemotherapeutic regimen; antiemetic regimen; patient gender, age, weight, and height; and cycle number. The reference logistic model and two reduced-models derived from the latter were designed. The logistic models were subsequently validated by means of receiving operating characteristic curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 319 cycles involving 106 patients were studied. The metoclopramide regimen was administered in 66% of the cycles. The therapeutic failure rate was 21% for the metoclopramide regimen and 32% for the ondansetron treatment. The logistic model developed identified the type of chemotherapeutic regimen provided as the most significant prognostic variable (p &lt; 0.0001). Patient weight (odds ratio 1.64) and height (odds ratio 1.28) were identified as prognostic factors related with therapeutic failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The type of chemotherapeutic regimen administered and the anthropometric characteristics of the patients exert a clear conditioning effect on risks associated with therapeutic failure against acute emesis following high-dose cisplatin therapy. Such anthropometric parameters have not been previously identified as prognostic factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.19188","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T16:38:03Z","timestamp":1054658283000},"page":"573-579","source":"Crossref","is-referenced-by-count":2,"title":["Anthropometric and Pharmacotherapeutic Variables on Acute Emesis Induced by Cisplatin-Containing Chemotherapy"],"prefix":"10.1177","volume":"34","author":[{"given":"Jos\u00e9 Luis Catal\u00e1n","family":"Arlandis","sequence":"first","affiliation":[{"name":"Jos\u00e9 Luis Catal\u00e1n Arlandis PharmD, Staff Pharmacist, Servicio Especial de Urgencias, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N V\u00edctor Jim\u00e9nez","family":"Torres","sequence":"additional","affiliation":[{"name":"N V\u00edctor Jim\u00e9nez Torres PharmD, Head, Pharmacy Service, Hospital Universitario Dr. Peset; Full Professor, Departamento de Farmacia y Tecnolog\u00eda Farmac\u00e9utica, Universidad de Valencia, Valencia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"bibr1-aph.19188","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(83)90418-2"},{"key":"bibr2-aph.19188","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050078"},{"issue":"5","key":"bibr3-aph.19188","first-page":"109","volume":"21","author":"Comis RL","year":"1994","journal-title":"Semin Oncol"},{"key":"bibr4-aph.19188","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890201)63:3<604::AID-CNCR2820630334>3.0.CO;2-2"},{"key":"bibr5-aph.19188","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.1.141"},{"key":"bibr6-aph.19188","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1693"},{"key":"bibr7-aph.19188","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057871"},{"key":"bibr8-aph.19188","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90162-7"},{"key":"bibr9-aph.19188","volume-title":"Applied regression analysis and other multivariate methods","author":"Kleinbaum DG","year":"1988","edition":"2"},{"key":"bibr10-aph.19188","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4108-7_1"},{"key":"bibr11-aph.19188","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4108-7_4"},{"key":"bibr12-aph.19188","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4108-7_5"},{"key":"bibr13-aph.19188","volume-title":"SPSS para Windows","author":"Lizasoain L","year":"1995"},{"key":"bibr14-aph.19188","first-page":"307","volume":"29","author":"Hanley JA","year":"1989","journal-title":"CRC Crit Rev Diagnostic Imaging"},{"key":"bibr15-aph.19188","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780101205"},{"key":"bibr16-aph.19188","volume-title":"The student edition of Matlab: version 5.0. 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