{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:47Z","timestamp":1777417127379,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2000,6]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report a case of international normalized ratio (INR) elevation resulting from the administration of topical methyl salicylate in a patient whose INR was previously stable while she received warfarin anticoagulation.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY:<\/jats:title>\n A 22-year-old white woman presented with an INR of 12.2 after applying a topical pain-relieving gel to her knees daily for eight days. The potentiation of the warfarin anticoagulation was attributed to the low-dose methyl salicylate contained in the product.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n Methyl salicylate is systemically absorbed through the skin in measurable amounts, and may increase warfarin action by affecting vitamin K metabolism or by displacing warfarin from protein-binding sites. While several investigators have reported this interaction with use of high-dose methyl salicylate, this case indicates that a significant interaction can occur with the use of lower topical doses of methyl salicylate as well.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Healthcare providers and patients taking warfarin must be aware of the potential hazard of using topical methyl salicylate in combination with warfarin.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.19309","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T16:38:04Z","timestamp":1054658284000},"page":"729-733","source":"Crossref","is-referenced-by-count":27,"title":["Potentiation of Warfarin Anticoagulation Associated with Topical Methyl Salicylate"],"prefix":"10.1177","volume":"34","author":[{"given":"Jacqueline D","family":"Joss","sequence":"first","affiliation":[{"name":"Jacqueline D Joss PharmD, Clinical Pharmacy Specialist, Ambulatory Care, Department of Pharmaceutical Care, University of Iowa Health Care, Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F","family":"LeBlond","sequence":"additional","affiliation":[{"name":"Richard F LeBlond MD, Professor, Clinical Internal Medicine, University of Iowa Health Care"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,6,1]]},"reference":[{"key":"bibr1-aph.19309","volume-title":"Drug facts and comparisons","author":"Burnham T","year":"1999"},{"key":"bibr2-aph.19309","doi-asserted-by":"publisher","DOI":"10.1177\/096032719601500905"},{"key":"bibr3-aph.19309","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.775.367"},{"key":"bibr4-aph.19309","doi-asserted-by":"publisher","DOI":"10.1177\/014107688908200821"},{"key":"bibr5-aph.19309","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1995.tb01540.x"},{"key":"bibr6-aph.19309","first-page":"403","volume":"36","author":"Chan TYK","year":"1998","journal-title":"Int J Clin Pharmacol Ther"},{"key":"bibr7-aph.19309","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440210038022"},{"key":"bibr8-aph.19309","first-page":"278","volume":"50","author":"Ramanathan M","year":"1995","journal-title":"Med J Malaysia"},{"key":"bibr9-aph.19309","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.3.411"},{"key":"bibr10-aph.19309","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190157"},{"key":"bibr11-aph.19309","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1970.tb08058.x"},{"key":"bibr12-aph.19309","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1981.tb13695.x"},{"key":"bibr13-aph.19309","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(86)90109-X"},{"key":"bibr14-aph.19309","first-page":"95","volume":"128","author":"Quick AJ","year":"1960","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr15-aph.19309","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197108262850905"},{"key":"bibr16-aph.19309","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197109022851005"},{"key":"bibr17-aph.19309","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502901214"},{"key":"bibr18-aph.19309","doi-asserted-by":"publisher","DOI":"10.1007\/BF00870985"},{"key":"bibr19-aph.19309","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:03:29Z","timestamp":1777374209000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.19309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1345\/aph.19309"],"URL":"https:\/\/doi.org\/10.1345\/aph.19309","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}