{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:59:39Z","timestamp":1777417179111,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2000,7]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report the development of a possible serotonin syndrome in a patient taking buspirone and fluoxetine.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY:<\/jats:title>\n A 37-year-old white man taking fluoxetine 20 mg\/d for generalized anxiety disorder developed confusion, diaphoresis, incoordination, diarrhea, and myoclonus after buspirone was added to the drug regimen.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n \n Serotonin syndrome is a potentially lethal condition of serotonin hyperstimulation, which may develop rapidly or over the course of several weeks. Symptoms of serotonin syndrome typically occur following additions or increases of serotonin-enhancing drugs. Although buspirone has variable effects on post- and presynaptic 5-HT\n 1A<\/jats:sub>\n receptors that may reduce the risk of serotonin syndrome when administered as a single agent, it may cause an adverse reaction when given with other serotonergic drugs.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Symptoms consistent with serotonin syndrome may develop with the concurrent administration of buspirone and fluoxetine.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.19341","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T16:38:38Z","timestamp":1054658318000},"page":"871-874","source":"Crossref","is-referenced-by-count":29,"title":["Possible Serotonin Syndrome Associated with Buspirone Added to Fluoxetine"],"prefix":"10.1177","volume":"34","author":[{"given":"Gail H","family":"Manos","sequence":"first","affiliation":[{"name":"Gail H Manos MD, Assistant Training Director, Department of Psychiatry, Naval Medical Center-Portsmouth, Portsmouth, VA 23708, FAX 757\/953-7416"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"bibr1-aph.19341","first-page":"269","volume":"54","author":"Joffe RT","year":"1993","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"bibr2-aph.19341","first-page":"3","volume":"12","author":"Sussman N","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"bibr3-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199906000-00012"},{"key":"bibr4-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199202000-00027"},{"key":"bibr5-aph.19341","doi-asserted-by":"publisher","DOI":"10.1177\/070674379003500823"},{"key":"bibr6-aph.19341","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.1.167a"},{"key":"bibr7-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199010000-00024"},{"key":"bibr8-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198904000-00024"},{"key":"bibr9-aph.19341","first-page":"222","volume":"51","author":"Feighner J P","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"bibr10-aph.19341","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.10.1565"},{"key":"bibr11-aph.19341","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(86)90287-8"},{"key":"bibr12-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199706000-00012"},{"key":"bibr13-aph.19341","doi-asserted-by":"publisher","DOI":"10.1177\/070674379504000721"},{"key":"bibr14-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199701000-00010"},{"key":"bibr15-aph.19341","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(92)72007-6"},{"key":"bibr16-aph.19341","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199606000-00034"},{"key":"bibr17-aph.19341","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.6.705"},{"key":"bibr18-aph.19341","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300111"},{"key":"bibr19-aph.19341","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90325-6"},{"key":"bibr20-aph.19341","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936040-00003"},{"key":"bibr21-aph.19341","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199700321-00003"},{"key":"bibr22-aph.19341","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-3-199402010-00009"},{"key":"bibr23-aph.19341","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.2636"},{"key":"bibr24-aph.19341","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr25-aph.19341","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(86)90577-0"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.19341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:03:37Z","timestamp":1777374217000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.19341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":25,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1345\/aph.19341"],"URL":"https:\/\/doi.org\/10.1345\/aph.19341","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}