{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:30:17Z","timestamp":1791178217391,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To evaluate the literature regarding the potential of acetaminophen to cause toxicity in adult patients without risk factors, when used chronically in daily doses \u22644 g.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>Key tertiary literature was reviewed, along with searches of MEDLINE (1966\u2013July 2001), International Pharmaceutical Abstracts (1970\u2013May 2001), and PREMEDLINE (July Week 5, 2001). Key search terms included acetaminophen, paracetamol, toxic hepatitis, hepatotoxicity, liver dysfunction, overdose, drug toxicity, and poisoning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Most tertiary references state that the maximum daily dose of acetaminophen is 4 g. Patients taking more than this amount, especially those with certain risk factors, are more likely to develop toxicity. However, a few patients may develop toxicity regardless of risk. An evaluation of the literature regarding the toxic potential of acetaminophen when given at doses \u22644 g\/d chronically (\u22654 d) to adult patients without risk factors was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Acetaminophen should be used cautiously on a chronic basis because several case reports show that it may be hepatotoxic at therapeutic doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1a035","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:20:34Z","timestamp":1054743634000},"page":"331-333","source":"Crossref","is-referenced-by-count":46,"title":["Hepatotoxicity Associated with Chronic Acetaminophen Administration in Patients without Risk Factors"],"prefix":"10.1177","volume":"36","author":[{"given":"Scott","family":"Bolesta","sequence":"first","affiliation":[{"name":"Scott Bolesta PharmD, Critical Care Specialty Resident, Department of Pharmacy, University of Kentucky Chandler Medical Center, Lexington, KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L","family":"Haber","sequence":"additional","affiliation":[{"name":"Stacy L Haber PharmD, Clinical Assistant Professor, College of Pharmacy, The University of Arizona; Director of Drug Information, Arizona Poison and Drug Information Center, Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,2,1]]},"reference":[{"key":"bibr-bibr1-aph.1A035","first-page":"41","volume-title":"Handbook of nonprescription drugs","author":"Lipman AG","year":"2000","edition":"12"},{"key":"bibr-bibr2-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198802000-00016"},{"key":"bibr-bibr3-aph.1A035","first-page":"541","volume-title":"Goldfrank's toxicologic emergencies","author":"Smilkstein MJ","year":"1998","edition":"6"},{"key":"bibr-bibr4-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70479-2"},{"key":"bibr-bibr5-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb03873.x"},{"key":"bibr-bibr6-aph.1A035","first-page":"275","volume-title":"Davies's textbook of adverse drug reactions","author":"Davis M","year":"1998","edition":"5"},{"key":"bibr-bibr7-aph.1A035","first-page":"1106","volume-title":"Pharmacotherapy: A pathophysiologic approach","author":"Doering PL","year":"1999","edition":"4"},{"key":"bibr-bibr8-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520230055038"},{"key":"bibr-bibr9-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90237-1"},{"key":"bibr-bibr10-aph.1A035","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-3-299"},{"key":"bibr-bibr11-aph.1A035","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-3-302"},{"key":"bibr-bibr12-aph.1A035","first-page":"208","volume":"51","author":"Emby DJ","year":"1977","journal-title":"S Afr Med J"},{"key":"bibr-bibr13-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90740-7"},{"key":"bibr-bibr14-aph.1A035","first-page":"385","volume":"70","author":"Goldfinger R","year":"1978","journal-title":"Am J Gastroenterol"},{"key":"bibr-bibr15-aph.1A035","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-2-267"},{"key":"bibr-bibr16-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03310030027020"},{"key":"bibr-bibr17-aph.1A035","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-4-511_1"},{"key":"bibr-bibr18-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(80)80103-1"},{"key":"bibr-bibr19-aph.1A035","first-page":"1310","volume":"78","author":"LaBrecque DR","year":"1980","journal-title":"Gastroenterology"},{"key":"bibr-bibr20-aph.1A035","first-page":"530","volume":"76","author":"Johnson MW","year":"1981","journal-title":"Am J Gastroenterol"},{"key":"bibr-bibr21-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1007\/BF02208663"},{"key":"bibr-bibr22-aph.1A035","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190511"},{"key":"bibr-bibr23-aph.1A035","first-page":"168","volume-title":"Meyler's side effects of drugs: An encyclopedia of adverse drug reactions and interactions","author":"Scott A","year":"1992","edition":"12"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1A035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1A035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:58Z","timestamp":1777374358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1A035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":23,"aliases":["10.1345\/1542-6270(2002)036<0331:hawcaa>2.0.co;2"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1345\/aph.1A035"],"URL":"https:\/\/doi.org\/10.1345\/aph.1a035","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}