{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:18:52Z","timestamp":1791357532558,"version":"4.3.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To compare the benefits and risks of bupropion and selective serotonin-reuptake inhibitors (SSRIs) in adults with depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>MEDLINE (1966\u2013September 1999), Embase (1980\u2013August 1999), PsycINFO (1887\u2013August 1999), International Pharmaceutical Abstracts (1970\u2013August 1999), and CIANHL databases were searched. References from the selected citations, review articles, and the manufacturer were also screened.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY SELECTION:<\/jats:title>\n                    <jats:p>Included studies were randomized, double-blind, controlled trials evaluating bupropion versus SSRIs for depression in adults. Studies were assessed independently in duplicate. Discrepancies were resolved by consensus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA ANALYSIS:<\/jats:title>\n                    <jats:p>Data are reported as absolute weighted mean differences or relative risks and 95% confidence intervals comparing bupropion relative to SSRIs. Data not combined are presented qualitatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Six full-length studies were included of 257 citations identified. SSRI comparators were fluoxetine, sertraline, and paroxetine. No differences in Hamilton Rating Scale for Depression (HAM-D) and Clinical Global Impressions Scale for Improvement of Illness (CGI-I) were found, but data were not able to be quantitatively combined. The absolute weighted mean differences were 0.10 (95% CI \u22120.2 to 0.4) for the CGI for Severity of Illness and 0.37 (95% CI \u22120.85 to 1.6) for the Hamilton Rating Scale for Anxiety measurements. Relative risks of bupropion compared with SSRIs were 0.6 (95% CI 0.41 to 0.89), 0.31 (95% CI 0.16 to 0.57), and 0.27 (95% CI 0.15 to 0.48) for nausea, diarrhea, and somnolence, respectively. Sexual arousal disorder, orgasmic dysfunction, and sexual desire disorder occurred less with bupropion than with SSRIs, with relative risks of 0.46 (95% CI 0.26 to 0.83), 0.22 (95% CI 0.12 to 0.40), and 0.65 (95% CI 0.51 to 0.84), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Bupropion and SSRIs have similar effectiveness; however, bupropion was associated with less nausea, diarrhea, somnolence, and sexual dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1a099","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T17:52:04Z","timestamp":1054662724000},"page":"1608-1613","source":"Crossref","is-referenced-by-count":51,"title":["Bupropion versus Selective Serotonin-Reuptake Inhibitors for Treatment of Depression"],"prefix":"10.1177","volume":"35","author":[{"given":"Carmine E","family":"Nieuwstraten","sequence":"first","affiliation":[{"name":"Carmine E Nieuwstraten BScPhm, Pharmacist, Department of Pharmacy, St. Joseph's Healthcare, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R","family":"Dolovich","sequence":"additional","affiliation":[{"name":"Lisa R Dolovich PharmD, Pharmacotherapy Specialist, Department of Pharmacy, St. Joseph's Healthcare; Scientist, Centre for Evaluation of Medicines, St. Joseph's Healthcare; Assistant Professor, Faculty of Pharmacy, University of Toronto, Toronto, Ontario; Assistant Professor, Department of Family Practice, McMaster University, Hamilton, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"bibr-bibr1-aph.1A099","volume-title":"Canadian Network for Mood and Anxiety Treatments: guidelines for the diagnosis and pharmacological treatment of depression","year":"1999","edition":"1"},{"key":"bibr-bibr2-aph.1A099","first-page":"395","volume":"56","author":"Ascher JA","year":"1995","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr3-aph.1A099","first-page":"101","volume":"44","author":"Halaris AE","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr4-aph.1A099","first-page":"104","volume":"44","author":"Zung WW","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr5-aph.1A099","first-page":"88","volume":"44","author":"Fabre LF","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr6-aph.1A099","first-page":"95","volume":"44","author":"Pitts WM","year":"1983","journal-title":"J Clin Psychiatry"},{"key":"bibr-bibr7-aph.1A099","first-page":"195","volume":"51","author":"Lineberry CG","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"bibr-bibr8-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433415"},{"key":"bibr-bibr9-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(98)80060-X"},{"key":"bibr-bibr10-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.4.525"},{"issue":"5","key":"bibr-bibr11-aph.1A099","first-page":"85","volume":"44","author":"Meredith CH","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr12-aph.1A099","first-page":"115","volume":"44","author":"Davidson J","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr13-aph.1A099","first-page":"118","volume":"44","author":"Mendels J","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr14-aph.1A099","first-page":"121","volume":"44","author":"Chouinard G","year":"1983","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr15-aph.1A099","first-page":"152","volume":"44","author":"Othmer E","year":"1983","journal-title":"J Clin Psychiatry"},{"key":"bibr-bibr16-aph.1A099","first-page":"310","volume":"49","author":"Othmer SC","year":"1988","journal-title":"J Clin Psychiatry"},{"key":"bibr-bibr17-aph.1A099","first-page":"72","volume":"18","author":"Harto-Truax N","year":"1982","journal-title":"Psychopharmacol Bull"},{"key":"bibr-bibr18-aph.1A099","first-page":"391","volume":"55","author":"Sachs GS","year":"1994","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"bibr-bibr19-aph.1A099","first-page":"130","volume":"44","author":"Branconnier RJ","year":"1983","journal-title":"J Clin Psychiatry"},{"key":"bibr-bibr20-aph.1A099","first-page":"339","volume":"33","author":"Shopsin B","year":"1983","journal-title":"Curr Ther Res Clin Exp"},{"key":"bibr-bibr21-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(05)80779-9"},{"key":"bibr-bibr22-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198602000-00006"},{"key":"bibr-bibr23-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199406000-00004"},{"key":"bibr-bibr24-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440060089011"},{"key":"bibr-bibr25-aph.1A099","unstructured":"Cochrane Library: Available at: URL: http:\/\/www.cochrane.org [accessed June 2000]."},{"key":"bibr-bibr26-aph.1A099","first-page":"329","volume":"52","author":"Feighner JP","year":"1991","journal-title":"J Clin Psychiatry"},{"key":"bibr-bibr27-aph.1A099","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n1204"},{"key":"bibr-bibr28-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200004000-00002"},{"key":"bibr-bibr29-aph.1A099","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0309"},{"key":"bibr-bibr30-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)88317-4"},{"key":"bibr-bibr31-aph.1A099","doi-asserted-by":"publisher","DOI":"10.3109\/10401239909147072"},{"key":"bibr-bibr32-aph.1A099","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199708000-00004"},{"key":"bibr-bibr33-aph.1A099","unstructured":"Giakas WJ, Miller HL, Hensala JD, Rohrbaugh R, Salomon RM, Licinio J, Fluoxetine versus bupropion in geriatric depression (abstract NR479). 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