{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:12:12Z","timestamp":1777417932245,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a patient with reversible breast enlargement due to D-penicillamine treatment for scleroderma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 55-year-old white woman developed enlarged breasts during D-penicillamine therapy for scleroderma. The enlargement regressed following discontinuation of the drug, and planned breast reduction surgery was avoided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>D-Penicillamine has been used in the treatment of various diseases including scleroderma. Breast enlargement has been previously described as a rare adverse effect of this drug. The enlargement subsided following discontinuation of the medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Attention is called to this rare adverse effect in an effort to avoid unnecessary diagnostic or therapeutic procedures, including surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1a229","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:20:40Z","timestamp":1054743640000},"page":"444-445","source":"Crossref","is-referenced-by-count":11,"title":["Breast Enlargement Induced by D-Penicillamine"],"prefix":"10.1177","volume":"36","author":[{"given":"Joseph Z","family":"Tchebiner","sequence":"first","affiliation":[{"name":"Joseph Z Tchebiner MD, Senior Attending Physician, Department of Medicine B, Tel Aviv\u2014Sourasky Medical Center; Clinical Instructor, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"bibr-bibr1-aph.1A229","first-page":"1294","volume":"15","author":"Craig HR","year":"1988","journal-title":"J Rheumatol"},{"key":"bibr-bibr2-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.2.200-a"},{"key":"bibr-bibr3-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6261.362-a"},{"key":"bibr-bibr4-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6276.1627-e"},{"key":"bibr-bibr5-aph.1A229","first-page":"990","volume":"12","author":"Kahl LE","year":"1985","journal-title":"J Rheumatol"},{"key":"bibr-bibr6-aph.1A229","first-page":"2265","volume":"13","author":"Salliere D","year":"1984","journal-title":"Presse Med"},{"key":"bibr-bibr7-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6348.1083-a"},{"key":"bibr-bibr8-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1984.tb03462.x"},{"key":"bibr-bibr9-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019110"},{"key":"bibr-bibr10-aph.1A229","first-page":"43","volume":"35","author":"Rose BI","year":"1990","journal-title":"J Reprod Med"},{"key":"bibr-bibr11-aph.1A229","first-page":"143","volume":"45","author":"Desautels JE","year":"1994","journal-title":"Can Assoc Radiol J"},{"key":"bibr-bibr12-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210130"},{"key":"bibr-bibr13-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(73)90043-X"},{"key":"bibr-bibr14-aph.1A229","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1A229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1A229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:09Z","timestamp":1777374369000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1A229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1345\/aph.1A229"],"URL":"https:\/\/doi.org\/10.1345\/aph.1a229","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}