{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:20:44Z","timestamp":1792192844293,"version":"4.4.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report the occurrence of hemorrhagic gastritis after topical isopropanol application in an infant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 2-year-old Hispanic boy developed coffee-ground emesis during emergency department evaluation for lethargy and fever. After an initial inconclusive workup for sepsis, further history revealed an isopropanol rubdown for fever reduction. Isopropanol concentrations and acetone metabolites were elevated, the patient recovered with supportive therapy, and other causes for hemorrhagic gastritis were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Isopropanol sponge bathing is commonly used as a home remedy for infants with fever. Topical absorption of isopropanol has previously been reported to cause mental status changes, ketosis, and metabolic acidosis. We report a case of hemorrhagic gastritis as a complication of topical isopropanol absorption in a febrile infant. An objective causality assessment revealed that the adverse event was probably caused by the isopropanol. Previous reports of pediatric isopropanol poisoning and its management are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Severe morbidity from topical isopropanol exposure may occur in young children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1a488","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:10:01Z","timestamp":1054743001000},"page":"1733-1735","source":"Crossref","is-referenced-by-count":25,"title":["Hemorrhagic Gastritis from Topical Isopropanol Exposure"],"prefix":"10.1177","volume":"36","author":[{"given":"Sara","family":"Dyer","sequence":"first","affiliation":[{"name":"Sara Dyer MD, Resident, Northwestern Memorial Hospital, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B","family":"Mycyk","sequence":"additional","affiliation":[{"name":"Mark B Mycyk MD, at time of writing, Fellow, Medical Toxicology, Toxikon Consortium\/Cook County Hospital, Chicago; now, Assistant Professor, Division of Emergency Medicine, Northwestern University Medical School, Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Ahrens","sequence":"additional","affiliation":[{"name":"William R Ahrens MD, Associate Professor of Emergency Medicine, Attending Physician, University of Illinois Hospital, Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Zell-Kanter","sequence":"additional","affiliation":[{"name":"Michele Zell-Kanter PharmD, Coordinator, Toxikon Consortium\/Cook County Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"bibr-bibr1-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2000.9261"},{"key":"bibr-bibr2-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1953.63690040001007"},{"key":"bibr-bibr3-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1542\/peds.43.4.622"},{"key":"bibr-bibr4-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(58)80219-X"},{"key":"bibr-bibr5-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199404000-00008"},{"key":"bibr-bibr6-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-1124(77)80208-6"},{"key":"bibr-bibr7-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200008000-00005"},{"key":"bibr-bibr8-aph.1A488","doi-asserted-by":"publisher","DOI":"10.3109\/15563659309000415"},{"key":"bibr-bibr9-aph.1A488","doi-asserted-by":"publisher","DOI":"10.3109\/15563659109038593"},{"key":"bibr-bibr10-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(92)90179-2"},{"key":"bibr-bibr11-aph.1A488","first-page":"233","volume":"28","author":"Martinez TT","year":"1986","journal-title":"Vet Hum Toxicol"},{"key":"bibr-bibr12-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90456-4"},{"key":"bibr-bibr13-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530030100022"},{"key":"bibr-bibr14-aph.1A488","first-page":"769","volume-title":"Clinical toxicology","author":"Ford MD","year":"2001"},{"key":"bibr-bibr15-aph.1A488","first-page":"1058","volume-title":"Goldfrank's toxicologic emergencies","author":"Goldfrank LR","year":"1998","edition":"6"},{"key":"bibr-bibr16-aph.1A488","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1A488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1A488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:40Z","timestamp":1777374340000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1A488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1345\/aph.1A488"],"URL":"https:\/\/doi.org\/10.1345\/aph.1a488","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}