{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:09:30Z","timestamp":1777417770441,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To review the efficacy and safety data of amlodipine and the angiotensin-receptor blockers (ARBs), focusing on heart failure, angina, percutaneous coronary intervention (PCI), and renal protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCE:<\/jats:title>\n                    <jats:p>A MEDLINE search (1966\u2013December 2001) was completed using amlodipine, angiotensin-receptor antagonist, losartan, valsartan, candesartan, and telmisartan as key words. English-language articles were identified and included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY SELECTION AND DATA EXTRACTION:<\/jats:title>\n                    <jats:p>All identified articles were evaluated. Articles representative of the subject matter of our review were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Amlodipine and the ARBs lower blood pressure to a similar extent. Amlodipine is an effective antianginal agent, whereas ARBs are not. However, amlodipine is not effective in the treatment of heart failure; ARBs may be useful in this setting. ARBs are also effective in preserving renal function and may provide some protection from restenosis in patients who have had a PCI. The ARBs may also be useful in preventing both diabetic and nondiabetic nephropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Concomitant disease states should be considered when choosing between an ARB and amlodipine for the management of hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c102","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:10:01Z","timestamp":1054743001000},"page":"1759-1766","source":"Crossref","is-referenced-by-count":0,"title":["Amlodipine versus Angiotensin-Receptor Blockers for Nonhypertension Indications"],"prefix":"10.1177","volume":"36","author":[{"given":"James S","family":"Kalus","sequence":"first","affiliation":[{"name":"James S Kalus PharmD, Cardiovascular Pharmacology Fellow, Hartford Hospital\/University of Connecticut, Hartford, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Michael","family":"White","sequence":"additional","affiliation":[{"name":"C Michael White PharmD, Assistant Professor of Pharmacy Practice, University of Connecticut; Co-Director of Arrhythmia Research, Hartford Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"bibr-bibr1-aph.1C102","first-page":"1146","volume":"32","author":"White CM","year":"1997","journal-title":"Formulary"},{"key":"bibr-bibr2-aph.1C102","unstructured":"Latner AW. 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