{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:11:57Z","timestamp":1777417917234,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report the development of nephrogenic diabetes insipidus (NDI) associated with the use of high-dose liposomal amphotericin B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY<\/jats:title>\n                    <jats:p>A 38-year-old white man with relapsed acute myelogenous leukemia underwent a matched unrelated donor allogeneic bone marrow transplant with adequate engraftment and mild graft-versus\u2013host disease responding to corticosteroids. Approximately 11 months after transplant, the patient was admitted to the hospital with suspected fungal pneumonia and started on liposomal amphotericin B (baseline serum creatinine 1.4\u20131.5 mg\/dL). The dose was increased due to his immunosuppression and poor response, as the fungal etiology was identified as Torulopsis glabrata. The patient required mechanical ventilation due to biopsy-proven bronchiolitis olbiterans organizing pneumonia. Additionally, he developed diffuse alveolar hemorrhage and received intravenous desmopressin, with a reduction in bloody secretions. He also developed hypernatremia (serum sodium 155 mEq\/L) on day 3 of the desmopressin and had an inappropriately increased urine output consistent with NDI. The most likely etiology for the NDI was liposomal amphotericin B and its associated hypokalemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The observation of worsening hypernatremia (serum sodium increased from 135 to 164 mEq\/L) with polyuria was associated with an increasing cumulative dosage of liposomal amphotericin B for fungal pneumonia despite the concurrent use of intravenous desmopressin. Aggressive water replacement was an effective treatment option in this patient. The Naranjo probability scale classified this as a possible adverse reaction because of the temporal sequence of NDI after high-dose liposomal amphotericin B and previously reported cases of NDI associated with amphotericin B desoxycholate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Amphotericin B desoxycholate has been implicated as an etiology for NDI, and the use of the newer liposomal amphotericin B reportedly avoids this rare complication. We observed the development of NDI despite the use of liposomal amphotericin B in a critically ill patient with bone marrow transplant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c204","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:28:03Z","timestamp":1054744083000},"page":"70-73","source":"Crossref","is-referenced-by-count":14,"title":["Possible Liposomal Amphotericin B\u2013Induced Nephrogenic Diabetes Insipidus"],"prefix":"10.1177","volume":"37","author":[{"given":"Todd W","family":"Canada","sequence":"first","affiliation":[{"name":"Todd W Canada PharmD BCNSP, Clinical Pharmacy Specialist, Division of Pharmacy, Unit 90, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M","family":"Weavind","sequence":"additional","affiliation":[{"name":"Lisa M Weavind MD, Critical Care Physician, Division of Critical Care\/Anesthesiology, Unit 42, The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristan M","family":"Augustin","sequence":"additional","affiliation":[{"name":"Kristan M Augustin PharmD BCOP, Clinical Pharmacy Specialist, Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"bibr1-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1086\/339215"},{"key":"bibr2-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1086\/517214"},{"key":"bibr3-aph.1C204","first-page":"107","volume":"13","author":"Smith OP","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"bibr4-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199201000-00019"},{"key":"bibr5-aph.1C204","first-page":"634","volume-title":"Clinical disorders of fluid and electrolyte metabolism","author":"Morrison G","year":"1994","edition":"5"},{"key":"bibr6-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1979.03630380064021"},{"key":"bibr7-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1976.80"},{"key":"bibr8-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1007\/BF00180544"},{"key":"bibr9-aph.1C204","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921060-00002"},{"key":"bibr10-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(58)90379-6"},{"key":"bibr11-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760705"},{"key":"bibr12-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr13-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100598"},{"key":"bibr14-aph.1C204","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.6.548"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1C204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:07Z","timestamp":1777374367000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1C204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1345\/aph.1C204"],"URL":"https:\/\/doi.org\/10.1345\/aph.1c204","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}