{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:17:50Z","timestamp":1777418270898,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of persistent psychosis that developed during interferon alfa (IFN-\u03b1) therapy for chronic hepatitis B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 26-year-old man who was diagnosed with active chronic hepatitis B began treatment with IFN-\u03b1. Five months after initiation of therapy, he developed acute psychosis with prominent persecutory delusions and auditory hallucinations. Despite discontinuation of IFN-\u03b1 therapy and addition of antipsychotic drug treatment, only partial recovery from psychosis was observed after 4 months of hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Unlike many previously reported cases, this patient showed only partial recovery from psychosis, despite the discontinuation of IFN therapy. Except for receiving a relatively high dose of IFN-\u03b1 (10 million units 3 times\/wk), the patient did not have any previously proposed risk factors for developing psychiatric adverse effects. The Naranjo probability scale indicates a probable relationship between the acute psychosis and IFN therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Despite its rare occurrence, psychosis can emerge during IFN-\u03b1 therapy. This adverse effect may persist for several months, even after appropriate medical management. IFN-\u03b1 should be used with careful monitoring of patients' psychiatric status during all stages of therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c266","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:31:57Z","timestamp":1054744317000},"page":"384-387","source":"Crossref","is-referenced-by-count":26,"title":["Psychosis Associated with Interferon Alfa Therapy for Chronic Hepatitis B"],"prefix":"10.1177","volume":"37","author":[{"given":"Lut","family":"Tamam","sequence":"first","affiliation":[{"name":"Lut Tamam MD, Assistant Professor, Department of Psychiatry, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Yerdelen","sequence":"additional","affiliation":[{"name":"Deniz Yerdelen MD, Resident, Department of Neurology, Faculty of Medicine, Cukurova University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurgul","family":"Ozpoyraz","sequence":"additional","affiliation":[{"name":"Nurgul Ozpoyraz MD, Professor, Department of Psychiatry, Faculty of Medicine, Cukurova University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"bibr1-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80184-X"},{"key":"bibr2-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.6.867"},{"key":"bibr3-aph.1C266","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-199911040-00002"},{"key":"bibr4-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(99)71208-9"},{"key":"bibr5-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10172"},{"key":"bibr6-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2000.00754.x"},{"key":"bibr7-aph.1C266","first-page":"157","volume":"96","author":"Ho SB","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"bibr8-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370090055011"},{"key":"bibr9-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04793-X"},{"key":"bibr10-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-8343(01)00135-9"},{"key":"bibr11-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(98)71296-4"},{"key":"bibr12-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(98)00073-4"},{"key":"bibr13-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199908000-00022"},{"key":"bibr14-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(01)00553-3"},{"key":"bibr15-aph.1C266","first-page":"1101","volume":"95","author":"Schafer M","year":"2000","journal-title":"Addiction"},{"key":"bibr16-aph.1C266","doi-asserted-by":"publisher","DOI":"10.3109\/13651500009178004"},{"key":"bibr17-aph.1C266","doi-asserted-by":"publisher","DOI":"10.3109\/13550289909015819"},{"key":"bibr18-aph.1C266","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1C266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:44Z","timestamp":1777374404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1C266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1345\/aph.1C266"],"URL":"https:\/\/doi.org\/10.1345\/aph.1c266","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}