{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:17:33Z","timestamp":1777418253101,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To present a single case of ampicillin-induced recurrent cholestasis and a literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 23-year-old man was hospitalized due to recurrent and self-limited cholestatic symptoms. He had used ampicillin before each cholestatic attack. He became well clinically and biochemically each time after cessation of the drug. One year after his recovery and discontinuance of ampicillin, the patient has had no recurrence of cholestasis. An objective causality assessment revealed that the adverse drug reaction was probable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Ampicillin-related hepatotoxicity is very rare, with injury being mainly hepatocellular. To our knowledge, there is only 1 case report in the literature referring to chronic cholestatic-type hepatotoxicity related to ampicillin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Ampicillin, which is one of the most widely used antibiotics, may cause recurrent cholestatic hepatitis. Clinicians should be aware of this adverse effect, and it should be kept in mind during diagnostic workup of liver injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c273","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T16:31:57Z","timestamp":1054744317000},"page":"395-397","source":"Crossref","is-referenced-by-count":14,"title":["Recurrent Cholestasis Due to Ampicillin"],"prefix":"10.1177","volume":"37","author":[{"given":"Seyfettin","family":"K\u00f6kl\u00fc","sequence":"first","affiliation":[{"name":"Seyfettin K\u00f6kl\u00fc MD, Research Fellow, Department of Gastroenterology, T\u00fcrkiye Y\u00fcksek ihtisas Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Osman Y\u00fcksel MD, Research Fellow, Department of Gastroenterology, T\u00fcrkiye Y\u00fcksek ihtisas Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Filik","sequence":"additional","affiliation":[{"name":"Levent Filik MD, Research Fellow, Department of Gastroenterology T\u00fcrkiye Y\u00fcksek ihtisas Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O\u011fuz","family":"\u00dcsk\u00fcdar","sequence":"additional","affiliation":[{"name":"O\u011fuz \u00dcsk\u00fcdar MD, Research Fellow, Department of Gastroenterology, T\u00fcrkiye Y\u00fcksek ihtisas Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadri","family":"Altunda\u011f","sequence":"additional","affiliation":[{"name":"Kadri Altunda\u011f MD, Associate Professor, Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Altiparmak","sequence":"additional","affiliation":[{"name":"Emin Altiparmak MD, Instructor, Department of Gastroenterology, T\u00fcrkiye Y\u00fcksek ihtisas Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"bibr1-aph.1C273","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199615010-00007"},{"key":"bibr2-aph.1C273","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10266"},{"key":"bibr3-aph.1C273","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90980-F"},{"key":"bibr4-aph.1C273","first-page":"1221","volume-title":"Sleisenger and Fordtran's gastrointestinal and liver disease","author":"Farrell GC","year":"1998","edition":"6"},{"key":"bibr5-aph.1C273","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/33.3.387"},{"key":"bibr6-aph.1C273","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61013-4_20"},{"key":"bibr7-aph.1C273","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6554.1072-a"},{"key":"bibr8-aph.1C273","first-page":"251","volume":"117","author":"Schaefer 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