{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:27:36Z","timestamp":1791826056580,"version":"4.3.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To describe the clinical course of a newborn (gestational age 38 wk, 6 d) administered intravenous nicardipine to control hypertension while on extracorporeal membrane oxygen (ECMO) support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>Urban, university teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 1-day-old male neonate presenting with a left congenital diaphragmatic hernia developed a sustained elevation in blood pressure following a change of ECMO tubing. After several unsuccessful treatment regimens, nicardipine was started at a rate of 0.5 \u03bcg\/kg\/min and aggressively titrated to 1.5 \u03bcg\/kg\/min. Nicardipine produced a sustained antihypertensive effect that was noticed 8 hours after the start of the infusion. The infusion was continued through postoperative day 2. Following a second circuit change, nicardipine was discontinued and sodium nitroprusside therapy was started. Treatment with nitroprusside failed to lower the blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Nicardipine is an effective antihypertensive agent for neonates receiving ECMO therapy. However, the expanded volume of distribution caused by the ECMO circuit may result in a reduced serum concentration and a reduced antihypertensive effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>We recommend a conservative initial dose of nicardipine of 0.5 \u03bcg\/kg\/min that is aggressively titrated to reduce blood pressure effectively in neonates receiving ECMO therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c366","type":"journal-article","created":{"date-parts":[[2003,4,22]],"date-time":"2003-04-22T17:04:35Z","timestamp":1051031075000},"page":"667-670","source":"Crossref","is-referenced-by-count":16,"title":["Nicardipine to Control Neonatal Hypertension During Extracorporeal Membrane Oxygen Support"],"prefix":"10.1177","volume":"37","author":[{"given":"Brian F","family":"McBride","sequence":"first","affiliation":[{"name":"Brian F McBride PharmD, Cardiovascular Pharmacology Fellow, Hartford Hospital, Hartford, CT; Assistant Clinical Professor of Pharmacy Practice, School of Pharmacy, University of Connecticut, Storrs-Mansfield, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Michael","family":"White","sequence":"additional","affiliation":[{"name":"C Michael White PharmD, Assistant Professor of Pharmacy Practice, School of Pharmacy, University of Connecticut; Co-Director of Cardiovascular and Arrhythmia Research, Hartford Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Campbell","sequence":"additional","affiliation":[{"name":"Margaret Campbell PharmD, Pediatric Clinical Coordinator, Connecticut Children's Medical Center; Assistant Clinical Professor of Pharmacy, School of Pharmacy, University of Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M","family":"Frey","sequence":"additional","affiliation":[{"name":"Bruce M Frey PharmD, Pediatric Pharmacotherapy Specialist, Thomas Jefferson University Hospital, Philadelphia, PA; Associate Professor of Clinical Pharmacy, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"bibr1-aph.1C366","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050771"},{"key":"bibr2-aph.1C366","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13449"},{"key":"bibr3-aph.1C366","first-page":"781","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Oates JA","year":"1996","edition":"9"},{"key":"bibr4-aph.1C366","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(95)00093-W"},{"key":"bibr5-aph.1C366","first-page":"109","volume":"23","author":"Tobias JD","year":"1996","journal-title":"Am J Anesthesiol"},{"key":"bibr6-aph.1C366","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200101000-00002"},{"key":"bibr7-aph.1C366","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051287"},{"key":"bibr8-aph.1C366","first-page":"92.1","volume-title":"Applied therapeutics: the clinical use of drugs","author":"Kraus DM","year":"2001","edition":"7"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1C366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:02Z","timestamp":1777374422000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1C366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1345\/aph.1C366"],"URL":"https:\/\/doi.org\/10.1345\/aph.1c366","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}