{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:12:23Z","timestamp":1777417943241,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report a case of delayed-onset dystonic reactions, oculogyric crisis (OGC), and torticollis after treatment with intramuscular haloperidol lactate injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>A 22-year-old Mexican American woman received intramuscular haloperidol lactate 7.5 mg followed 4 hours later by 10 mg. Twenty-six hours after the first injection, the patient reported that she was unable to lower her gaze and that her neck was stiff. She was immediately given intramuscular benztropine 2 mg; there was a nearly complete remission of symptoms within 15 minutes of treatment. An objective causality assessment revealed a probable relationship between the OGC\/torticollis and haloperidol therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Dystonic reactions have been reported in 10\u201360% of patients treated with neuroleptic medication, most commonly when patients just start or increase the dose of the drug. The highest frequency of dystonic reactions has occurred in patients receiving high-potency neuroleptics. It has also been suggested that haloperidol-induced dystonic reactions are a result of the toxic metabolites of that agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OGC and torticollis reactions may occur 12\u201324 hours after treatment with a high-potency neuroleptic, even in the absence of symptoms of extrapyramidal side effects (EPSEs). The delayed dystonic reaction may begin suddenly (no early EPSE symptomatology).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c389","type":"journal-article","created":{"date-parts":[[2003,8,15]],"date-time":"2003-08-15T13:04:54Z","timestamp":1060952694000},"page":"1434-1437","source":"Crossref","is-referenced-by-count":18,"title":["Delayed Onset of Oculogyric Crisis and Torticollis with Intramuscular Haloperidol"],"prefix":"10.1177","volume":"37","author":[{"given":"Stanford S","family":"Jhee","sequence":"first","affiliation":[{"name":"Stanford S Jhee PharmD, Director of Research, California Clinical Trials Medical Group, Glendale, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Zarotsky","sequence":"additional","affiliation":[{"name":"Victoria Zarotsky PharmD, Research Scientist, California Clinical Trials Medical Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M","family":"Mohaupt","sequence":"additional","affiliation":[{"name":"Stephen M Mohaupt MD, Research Psychiatrist, California Clinical Trials Medical Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia L","family":"Yones","sequence":"additional","affiliation":[{"name":"Cynthia L Yones RN, Inpatient Department Manager, California Clinical Trials Medical Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve J","family":"Sims","sequence":"additional","affiliation":[{"name":"Steve J Sims RN, Clinical Research Coordinator, California Clinical Trials Medical Group"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"bibr1-aph.1C389","first-page":"399","volume-title":"Goodman & Gilman's the pharmacological basis of therapeutics","author":"Baldessarini RJ","year":"1996","edition":"9"},{"key":"bibr2-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr3-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050130017010"},{"key":"bibr4-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.156.5.620"},{"key":"bibr5-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.132.5.532"},{"key":"bibr6-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.9.1231"},{"key":"bibr7-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.4.1"},{"key":"bibr8-aph.1C389","first-page":"305","volume":"47","author":"Sramek JJ","year":"1986","journal-title":"J Clin Psychiatry"},{"key":"bibr9-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.5.708"},{"key":"bibr10-aph.1C389","first-page":"21","volume-title":"Drug-induced movement disorders","author":"Casey DE","year":"1991"},{"key":"bibr11-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(99)90141-9"},{"key":"bibr12-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.156.3.412"},{"key":"bibr13-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810320063009"},{"key":"bibr14-aph.1C389","first-page":"258","volume":"169","author":"Singh MM","year":"1973","journal-title":"J Nerv Ment Dis"},{"key":"bibr15-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700047942"},{"key":"bibr16-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080117"},{"key":"bibr17-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198710000-00011"},{"key":"bibr18-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760130040006"},{"key":"bibr19-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050130017010"},{"key":"bibr20-aph.1C389","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937060-00001"},{"key":"bibr21-aph.1C389","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198917060-00004"},{"key":"bibr22-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.7.2173"},{"key":"bibr23-aph.1C389","volume-title":"Drug information handbook","author":"Lacy CF","year":"1999"},{"key":"bibr24-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00955-7"},{"key":"bibr25-aph.1C389","first-page":"159","volume":"14","author":"Tsang MW","year":"1994","journal-title":"J Clin Psychopharmacol"},{"key":"bibr26-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.1.48"},{"key":"bibr27-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810050096021"},{"key":"bibr28-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.2.173"},{"key":"bibr29-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820070032005"},{"key":"bibr30-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90288-O"},{"key":"bibr31-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198606000-00002"},{"key":"bibr32-aph.1C389","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810320063009"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1C389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:10Z","timestamp":1777374370000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1C389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1345\/aph.1C389"],"URL":"https:\/\/doi.org\/10.1345\/aph.1c389","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}