{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:49:01Z","timestamp":1791845341691,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>Searches of MEDLINE (1966\u2013November 2003) and EMBASE (1988\u2013November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c391","type":"journal-article","created":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T10:17:10Z","timestamp":1070619430000},"page":"146-150","source":"Crossref","is-referenced-by-count":64,"title":["Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children"],"prefix":"10.1177","volume":"38","author":[{"given":"Ran D","family":"Goldman","sequence":"first","affiliation":[{"name":"Ran D Goldman MD, Director, Pediatric Research in Emergency Therapeutics (PRETx) Program Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ko","sequence":"additional","affiliation":[{"name":"Karen Ko BSc, Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren J","family":"Linett","sequence":"additional","affiliation":[{"name":"Lauren J Linett BSc, Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Scolnik","sequence":"additional","affiliation":[{"name":"Dennis Scolnik MBChB, Staff Physician, Division of Pediatric Emergency Medicine, The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,1,1]]},"reference":[{"key":"bibr1-aph.1C391","first-page":"959","volume-title":"Primary pediatric care","author":"Van der Jagt EW.","year":"1997","edition":"3"},{"key":"bibr2-aph.1C391","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.100"},{"key":"bibr3-aph.1C391","unstructured":"Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of pediatrics. 16th ed. 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Paracetamol for treating fever in children. 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