{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:20:34Z","timestamp":1777418434041,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of possible cefotaxime-induced Stevens\u2013Johnson syndrome (SJS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 72-year-old woman with an upper urinary tract infection developed erosions and blisters on the skin and the mucous membranes, as well as fever and prostration, soon after the administration of cefotaxime. This presentation is consistent with the features of SJS. Resolution of the clinical manifestations was observed after discontinuation of the drug; all other drugs, infections, or immunologic disorders that could have caused this syndrome were carefully excluded. An objective causality assessment revealed that SJS was possibly associated with the use of cefotaxime.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Although cephalosporins have been associated with an increased risk for SJS and cefotaxime has been suspected of being associated with SJS in a previous case\u2013control study, this is the first full report for cefotaxime-related SJS in the literature. An immunologically mediated reaction may be the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Although cefotaxime administration seems to be the underlying cause of the SJS observed in our patient, establishment of a definite causal relationship requires additional cases and supportive data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1c453","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T12:40:58Z","timestamp":1050583258000},"page":"812-814","source":"Crossref","is-referenced-by-count":10,"title":["Possible Cefotaxime-Induced Stevens\u2013Johnson Syndrome"],"prefix":"10.1177","volume":"37","author":[{"given":"Evagelos N","family":"Liberopoulos","sequence":"first","affiliation":[{"name":"Evagelos N Liberopoulos MD, House Officer, Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L","family":"Liamis","sequence":"additional","affiliation":[{"name":"George L Liamis MD, Consultant of Internal Medicine, Department of Internal Medicine, School of Medicine, University of Ioannina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses S","family":"Elisaf","sequence":"additional","affiliation":[{"name":"Moses S Elisaf MD FACA FRSH, Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, University of Ioannina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"bibr1-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"bibr2-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332404"},{"key":"bibr3-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"bibr4-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198005000-00015"},{"key":"bibr5-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202601006"},{"key":"bibr6-aph.1C453","first-page":"390","volume":"81","author":"McArthur JE","year":"1975","journal-title":"N Z Med J"},{"key":"bibr7-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra993637"},{"key":"bibr8-aph.1C453","first-page":"5","volume":"8","author":"Ghislain PD","year":"2002","journal-title":"Dermatol Online"},{"key":"bibr9-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.62.727.415"},{"key":"bibr10-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700317"},{"key":"bibr11-aph.1C453","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1C453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1C453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:10Z","timestamp":1777374430000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1C453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1345\/aph.1C453"],"URL":"https:\/\/doi.org\/10.1345\/aph.1c453","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}