{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:28:46Z","timestamp":1777418926973,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To describe the first case, to the best of our knowledge, of posttraumatic Scedosporium apiospermum (ScA) keratitis successfully treated with systemic and topical voriconazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY<\/jats:title>\n                    <jats:p>A 19-year-old man was admitted to the hospital with an incisive wound of his left eye and the cornea totally sectioned after trauma with a cutter used in gardening. Initial empirical treatment was followed by systemic and topical voriconazole, and the eye did not have to be enucleated. Five months after the trauma, a penetrating keratoplasty and chamber intraocular lens implantation was performed with a favorable visual outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>ScA keratitis is rare, but it must be suspected if a history of ocular injury with contaminated objects exists. Among the antifungals available to treat ScA keratitis, voriconazole has shown advantages such as the lowest minimum inhibitory concentration and the availability of an oral formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Voriconazole shows promise as an effective alternative to conventional antifungals in the treatment of ScA keratitis. It is available both as oral and intravenous preparations, which is a great advantage in these lengthy infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1d128","type":"journal-article","created":{"date-parts":[[2004,2,2]],"date-time":"2004-02-02T20:12:57Z","timestamp":1075752777000},"page":"414-417","source":"Crossref","is-referenced-by-count":47,"title":["Voriconazole in Fungal Keratitis Caused by\n                    <i>Scedosporium apiospermum<\/i>"],"prefix":"10.1177","volume":"38","author":[{"given":"Hern\u00e1ndez Carmen","family":"Prats","sequence":"first","affiliation":[{"name":"Carmen Hern\u00e1ndez Prats PharmD, Clinical Pharmacist, Pharmacy Department, Alicante University General Hospital, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca Llinares","family":"Tello","sequence":"additional","affiliation":[{"name":"Francisca Llinares Tello PharmD PhD, Clinical Pharmacist, Pharmacy Department, Alicante University General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo Burgos San","family":"Jos\u00e9","sequence":"additional","affiliation":[{"name":"Amparo Burgos San Jos\u00e9 PharmD, Clinical Specialist, Pharmacy Department, Alicante University General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Selva","family":"Otaolaurruchi","sequence":"additional","affiliation":[{"name":"Juan Selva Otaolaurruchi PharmD PhD, Clinical Specialist, Pharmacy Department, Alicante University General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo Ordov\u00e1s","family":"Baines","sequence":"additional","affiliation":[{"name":"Juan Pablo Ordov\u00e1s Baines PharmD PhD, Clinical Specialist; Director, Department of Pharmacy, Alicante University General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"bibr1-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75812-X"},{"key":"bibr2-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1159\/000007295"},{"key":"bibr3-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200207000-00016"},{"key":"bibr4-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200207000-00015"},{"key":"bibr5-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1989.tb02183.x"},{"key":"bibr6-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31225-5"},{"key":"bibr7-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1007\/BF01716706"},{"key":"bibr8-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1159\/000308814"},{"key":"bibr9-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200101000-00022"},{"key":"bibr10-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.1.149"},{"key":"bibr11-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1991.tb00864.x"},{"key":"bibr12-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.1.93"},{"key":"bibr13-aph.1D128","first-page":"1253","volume-title":"Cornea and external disease: clinical diagnosis and management","author":"Alphonso EC","year":"1998"},{"key":"bibr14-aph.1D128","first-page":"651","volume-title":"Medical mycology","author":"Rippon JW.","year":"1988"},{"key":"bibr15-aph.1D128","first-page":"469","volume":"92","author":"Pleyer U","year":"1995","journal-title":"Ophthalmologe"},{"key":"bibr16-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1020"},{"key":"bibr17-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200301000-00008"},{"key":"bibr18-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1086\/317496"},{"key":"bibr19-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1436-1438.1998"},{"key":"bibr20-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.8.928d"},{"key":"bibr21-aph.1D128","unstructured":"21. Ruokonen P, Tintelnot K, Kojetinsky C, Ruhnke M, Anders N. Voriconazole for treatment of ocular mould infection after failure of fluconazole and amphotericin B (abstract P 104). Presented at: 99th Annual Meeting of German Ophthalmological Society, Berlin, September 29\u2013October 2, 2001."},{"key":"bibr22-aph.1D128","doi-asserted-by":"publisher","DOI":"10.1086\/322653"},{"key":"bibr23-aph.1D128","unstructured":"23. Tomaszewski K, Purkins L. Visual effects with voriconazole (abstract A-639). Presented at: 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, December 16\u201319, 2001."}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1D128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:42Z","timestamp":1777374522000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1D128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1345\/aph.1D128"],"URL":"https:\/\/doi.org\/10.1345\/aph.1d128","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}