{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:28:11Z","timestamp":1777418891072,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report a probable case of Henoch-Sch\u00f6nlein purpura associated with acenocoumarol therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY<\/jats:title>\n                    <jats:p>A 76-year-old white woman was prescribed acenocoumarol for chronic atrial fibrillation. Two months after starting therapy, the patient came to our hospital's emergency department because of abdominal pain associated with vomiting. Physical examination revealed multiple round, confluent, purpuric lesions with some vesicles and an area of residual pigmentation. Lesions were present predominantly on the legs and gluteus, and also on the abdomen and arms. Skin biopsy of the lesions was compatible with leukocytoclastic vasculitis with deposition of immunoglobulin A. An upper intestinal endoscopy was done and identified purpuric mucosal lesions in the fundus, body, and antrum of the stomach and the duodenal bulb. Renal function was not affected, although proteinuria (1.26 g\/day) was found and microscopic hematuria was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The most likely cause of the Henoch\u2013Sch\u00f6nlein purpura in this case was considered to be acenocoumarol because of the close temporal relationship between exposure to the drug and onset of symptoms, as well as the rapid resolution of the symptoms and signs after acenocoumarol was discontinued. The oral anticoagulant was the only identifiable precipitant that the patient encountered before the Henoch\u2013Sch\u00f6nlein purpura developed. An objective causality assessment revealed that the adverse drug event was probable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This case report illustrates a probable association between Henoch\u2013Sch\u00f6nlein purpura and acenocoumarol. As of December 2003, this reaction had not been previously reported. Clinicians should be aware of this potential adverse effect of a widely used drug.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1d270","type":"journal-article","created":{"date-parts":[[2004,1,12]],"date-time":"2004-01-12T12:02:56Z","timestamp":1073908976000},"page":"261-264","source":"Crossref","is-referenced-by-count":15,"title":["Acenocoumarol-Induced Henoch-Sch\u00f6nlein Purpura"],"prefix":"10.1177","volume":"38","author":[{"given":"Joaqu\u00edn","family":"Borr\u00e1s-Blasco","sequence":"first","affiliation":[{"name":"Joaqu\u00edn Borr\u00e1s-Blasco PharmD PhD, Specialist in Hospital Pharmacy, Pharmacy Service, Hospital General Universitario de Elche, Elche, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Girona","sequence":"additional","affiliation":[{"name":"Eva Girona MD PhD, Specialist in Gastroenterology, Gastroenterology Section, Hospital General Universitario de Elche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Navarro-Ruiz","sequence":"additional","affiliation":[{"name":"Andr\u00e9s Navarro-Ruiz PharmD, Specialist in Hospital Pharmacy Pharmacy Service, Hospital General Universitario de Elche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Matarredona","sequence":"additional","affiliation":[{"name":"Jaime Matarredona MD, Specialist in Dermatology, Dermatology Section, Hospital General Universitario de Elche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Encarnaci\u00f3n","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Mar\u00eda Encarnaci\u00f3n Gim\u00e9nez MD, Specialist in Dermatology, Dermatology Section, Hospital General Universitario de Elche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Ana Guti\u00e9rrez MD 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