{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:57Z","timestamp":1777418877246,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of piperacillin\/tazobactam-induced rash in a patient with infectious mononucleosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 25-year-old white man developed a rash while receiving piperacillin\/tazobactam 3.375 g intravenously every 6 hours and gentamicin for osteomyelitis complicating a left femur fracture secondary to a motorcycle accident. Due to progression of the rash following additional doses of piperacillin\/tazobactam during hospitalization, the patient's antimicrobial regimen was changed to vancomycin and meropenem. Subsequently, a mononucleosis spot test was positive, and both Epstein\u2014Barr virus (EBV) immunoglobulin (Ig) G and IgM antibodies were positive. The rash rapidly resolved with the discontinuation of piperacillin\/tazobactam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Although the development of rash following the administration of several different antimicrobials, especially ampicillin, has been previously reported, this is the first report of piperacillin\/tazobactam-induced rash in infectious mononucleosis. The rash is generally self-limiting and usually resolves within days of discontinuing the causative antimicrobial agent. An altered drug metabolism or an immune-mediated process has been suggested as the potential mechanism for rash development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Prior reports of antimicrobial-induced rash in infectious mononucleosis and a positive laboratory diagnosis of EBV in our patient with no history of penicillin allergy support the identification of piperacillin\/tazobactam as the inducer of the rash. According to the Naranjo probability scale, the association of piperacillin\/tazobactam with the rash was classified as probable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1d378","type":"journal-article","created":{"date-parts":[[2004,5,3]],"date-time":"2004-05-03T20:28:41Z","timestamp":1083616121000},"page":"996-998","source":"Crossref","is-referenced-by-count":16,"title":["Rash Associated with Piperacillin\/Tazobactam Administration in Infectious Mononucleosis"],"prefix":"10.1177","volume":"38","author":[{"given":"Aim\u00e9e C","family":"LeClaire","sequence":"first","affiliation":[{"name":"Aim\u00e9e C LeClaire PharmD, Critical Care Specialty Pharmacy Resident, Chief Pharmacy Resident, Pharmacy Services, Chandler Medical Center, University of Kentucky, Lexington, KY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A","family":"Martin","sequence":"additional","affiliation":[{"name":"Craig A Martin PharmD, Infectious Diseases Clinical Specialist, Pharmacy Services, Chandler Medical Center, University of Kentucky; Assistant Professor, College of Pharmacy, University of Kentucky, Lexington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardis D","family":"Hoven","sequence":"additional","affiliation":[{"name":"Ardis D Hoven MD, Professor of Medicine, Division of Infectious Diseases, Department of Medicine, College of Medicine, University of Kentucky, Lexington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"bibr1-aph.1D378","first-page":"1599","volume-title":"Principles and practice of infectious disease","author":"Schooley RT","year":"2000","edition":"5"},{"key":"bibr2-aph.1D378","doi-asserted-by":"publisher","DOI":"10.1177\/000992287601500505"},{"key":"bibr3-aph.1D378","first-page":"493","volume":"7","author":"Geyman JP","year":"1978","journal-title":"J Fam Pract"},{"key":"bibr4-aph.1D378","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.4.697"},{"key":"bibr5-aph.1D378","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(87)90131-9"},{"key":"bibr6-aph.1D378","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199716010-00001"},{"key":"bibr7-aph.1D378","first-page":"330","volume":"83","author":"Pauszek ME","year":"1990","journal-title":"Indiana Med"},{"key":"bibr8-aph.1D378","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05021.x"},{"key":"bibr9-aph.1D378","first-page":"251","volume":"59","author":"McCloskey GL","year":"1997","journal-title":"Cutis"},{"key":"bibr10-aph.1D378","first-page":"91","volume":"64","author":"Lupton JR","year":"1999","journal-title":"Cutis"},{"key":"bibr11-aph.1D378","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000026949"},{"key":"bibr12-aph.1D378","first-page":"163","volume":"65","author":"Schissel DJ","year":"2000","journal-title":"Cutis"},{"key":"bibr13-aph.1D378","first-page":"214","volume":"26","author":"McKenzie H","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"bibr14-aph.1D378","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1D378","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:20Z","timestamp":1777374500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1D378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1345\/aph.1D378"],"URL":"https:\/\/doi.org\/10.1345\/aph.1d378","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}