{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:17:36Z","timestamp":1792192656789,"version":"4.4.0"},"reference-count":8,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,7]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report a case of delayed toxicity following a single ingestion of aspirin, where the initial concentrations were nearly undetectable and the patient was completely asymptomatic for the first 35 hours.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY:<\/jats:title>\n A 14-year-old white female was evaluated after a single ingestion of 120 tablets of aspirin 81 mg\/tablet hours before arrival to the emergency department. She denied nausea, abdominal pain, tinnitus, or shortness of breath. She received one dose of activated charcoal. The first salicylate concentration (4 h after ingestion) was 1 mg\/dL. At 35 hours, the patient became symptomatic (dizziness, tinnitus, epigastric discomfort). Her salicylate concentration at that time was 46 mg\/dL. A second dose of activated charcoal was administered, and intravenous bicarbonate with potassium was started as a continuous infusion for 30 hours.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n While delayed salicylate toxicity is well reported in the literature, no report was found regarding concentrations increasing to toxicity 35 hours after ingestion. The delayed aspirin absorption may be due to salicylate-induced pylorospasm or the formation of pharmacobezoars.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In cases with known salicylate ingestion, it is important to follow salicylate concentrations every 4 hours until they are steadily decreasing according to a 4-hour half-life and the patient shows no symptoms of salicylate intoxication.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1d575","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T20:18:09Z","timestamp":1086639489000},"page":"1186-1188","source":"Crossref","is-referenced-by-count":27,"title":["Delayed Salicylate Toxicity at 35 Hours Without Early Manifestations Following a Single Salicylate Ingestion"],"prefix":"10.1177","volume":"38","author":[{"given":"Wilfredo","family":"Rivera","sequence":"first","affiliation":[{"name":"Wilfredo Rivera MD, Clinical Instructor, Section of Toxicology, University of Texas Southwestern (UTSW) Emergency Medicine, Dallas, TX; Assistant Medical Director, North Texas Poison Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt C","family":"Kleinschmidt","sequence":"additional","affiliation":[{"name":"Kurt C Kleinschmidt MD, Associate Professor, UTSW Emergency Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa I","family":"Velez","sequence":"additional","affiliation":[{"name":"Larissa I Velez MD, Assistant Residency Director and Assistant Professor, UTSW Emergency Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greene","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Greene Shepherd PharmD, Director and Clinical Toxicologist, North Texas Poison Center; Clinical Assistant Professor, UTSW Emergency Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C","family":"Keyes","sequence":"additional","affiliation":[{"name":"Daniel C Keyes MD MPH, Associate Professor and Chief, Section of Toxicology, UTSW Emergency Medicine; Medical Director, North Texas Poison Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"bibr1-aph.1D575","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2002.34955"},{"key":"bibr2-aph.1D575","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb46905.x"},{"key":"bibr3-aph.1D575","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(87)80366-9"},{"key":"bibr4-aph.1D575","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90915-6"},{"key":"bibr5-aph.1D575","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80468-X"},{"key":"bibr6-aph.1D575","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1991.11700890"},{"key":"bibr7-aph.1D575","volume-title":"Clinical toxicology review\/bezoars","volume":"18","author":"Michael T","year":"1996"},{"key":"bibr8-aph.1D575","first-page":"688","volume":"40","author":"Salhanick S","year":"2002","journal-title":"Clin Toxicol"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1D575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:37Z","timestamp":1777374517000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1D575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":8,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1345\/aph.1D575"],"URL":"https:\/\/doi.org\/10.1345\/aph.1d575","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}