{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:25:44Z","timestamp":1777418744729,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,11]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To report a case of trimethoprim\/sulfamethoxazole (TMP\/SMX)-induced aseptic meningitis.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY<\/jats:title>\n An 18-year-old woman diagnosed with acute myeloid leukemia was admitted for a bone marrow transplant. She had already attained remission with daunorubicin, thioguanine, and high-dose cytarabine. A routine lumbar puncture performed on admission revealed an abnormally elevated leukocyte count, and meningitis was suspected. The patient had been taking TMP\/SMX (trimethoprim 120 mg) twice daily on Monday, Tuesday, and Wednesday for the past 3 months; no other medication was being used. Upon examination, the patient mentioned having had headaches for the past few weeks. Since viral, bacterial, and fungal cultures were negative, a diagnosis of aseptic meningitis was made. According to the Naranjo probability scale, TMP\/SMX was a possible cause of the aseptic meningitis. Eleven days after discontinuation of TMP\/SMX, lumbar puncture results had returned to normal.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Many drugs have been associated with aseptic meningitis. Antibiotics are often linked with aseptic meningitis, with TMP\/SMX being the most frequently associated antibiotic. Many cases of TMP\/SMX-induced aseptic meningitis have been reported, while few cases have been reported with trimethoprim and sulfamethoxazole given separately.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Despite the widespread use of TMP\/SMX and the years of experience we have had with the drug, it is important to remain vigilant regarding possible adverse effects, particularly aseptic meningitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1d581","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T23:44:56Z","timestamp":1095205496000},"page":"1863-1867","source":"Crossref","is-referenced-by-count":14,"title":["Possible Trimethoprim\/Sulfamethoxazole-Induced Aseptic Meningitis"],"prefix":"10.1177","volume":"38","author":[{"given":"Roxane","family":"Therrien","sequence":"first","affiliation":[{"name":"Roxane Therrien MSc, Pharmacist, Pharmacy Department, Centre Universitaire M\u00e8re-Enfant Ste-Justine, 3175 C\u00f4te Ste-Catherine, Montr\u00e9al, Quebec H3T 1C5, Canada, fax 514\/345-4899, roxane."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"bibr1-aph.1D581","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200022030-00005"},{"key":"bibr2-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202600613"},{"key":"bibr3-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.7.615"},{"key":"bibr4-aph.1D581","volume-title":"Principles and practice of infectious diseases","author":"Mandell G","year":"2000","edition":"5"},{"key":"bibr5-aph.1D581","doi-asserted-by":"publisher","DOI":"10.2174\/1568008033340243"},{"key":"bibr6-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9427"},{"key":"bibr7-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.11.1185"},{"key":"bibr8-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.3.431"},{"key":"bibr9-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.3.257"},{"key":"bibr10-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402063"},{"key":"bibr11-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050048"},{"key":"bibr12-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200101000-00022"},{"key":"bibr13-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30259-7"},{"key":"bibr14-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(94)90027-2"},{"key":"bibr15-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1986.tb02801.x"},{"key":"bibr16-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03350200051023"},{"key":"bibr17-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198306163082416"},{"key":"bibr18-aph.1D581","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1D581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1D581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:59Z","timestamp":1777374479000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1D581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1345\/aph.1D581"],"URL":"https:\/\/doi.org\/10.1345\/aph.1d581","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}