{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:32:30Z","timestamp":1777419150168,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of pulmonary hypersensitivity associated with furazolidone use and review the literature on this topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 43-year-old white female presented with fever and dyspnea. She had recently completed a course of furazolidone 125 mg 4 times daily for 10 days for enteritis. Investigations revealed bibasilar interstitial infiltrates on chest X-ray, hypoxia, and 21% eosinophilia. Her fever, hypoxia, and dyspnea rapidly abated following discontinuation of furazolidone and administration of corticoteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Furazolidone is a bactericidal agent used to treat infectious enteropathies. It is chemically similar to nitrofurantoin, which is well known to cause pulmonary hypersensitivity reactions. Application of the Naranjo probability scale suggests that a furazolidone adverse reaction in this patient was probable. A MEDLINE search from 1966 to October 2004 revealed 2 previously reported cases suggestive of furazolidone pulmonary hypersensitivity. All published reports closely resemble each other and descriptions of nitrofurantoin-associated pulmonary hypersensitivity reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Furazolidone may induce pulmonary hypersensitivity reactions; clinicians should be aware of this potentially serious adverse effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1e080","type":"journal-article","created":{"date-parts":[[2005,1,11]],"date-time":"2005-01-11T22:13:57Z","timestamp":1105481637000},"page":"377-379","source":"Crossref","is-referenced-by-count":12,"title":["Furazolidone-Induced Pulmonary Hypersensitivity"],"prefix":"10.1177","volume":"39","author":[{"given":"Todd J","family":"Kowalski","sequence":"first","affiliation":[{"name":"Todd J Kowalski MD, Infectious Diseases Fellow, Division of Infectious Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Henry","sequence":"additional","affiliation":[{"name":"Michael J Henry MD, Staff Physician, Department of Gastroenterology, Gundersen Lutheran Medical Center, La Crosse, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A","family":"Zlabek","sequence":"additional","affiliation":[{"name":"Jonathan A Zlabek MD, Staff Physician, Department of Internal Medicine, Gundersen Lutheran Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"bibr1-aph.1E080","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"bibr2-aph.1E080","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196911132812002"},{"key":"bibr3-aph.1E080","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr4-aph.1E080","first-page":"823","volume":"105","author":"Cortez LM","year":"1972","journal-title":"Am Rev Respir Dis"},{"key":"bibr5-aph.1E080","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.49.573.518"},{"key":"bibr6-aph.1E080","first-page":"465","volume":"97","author":"Zielonka TM","year":"1997","journal-title":"Pol Arch Med Wewn"},{"key":"bibr7-aph.1E080","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.1.3"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1E080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:09:36Z","timestamp":1777374576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1E080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1345\/aph.1E080"],"URL":"https:\/\/doi.org\/10.1345\/aph.1e080","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}