{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:29:43Z","timestamp":1777418983736,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To describe a case of cefoperazone-induced acute interstitial nephritis (AIN) in which the diagnosis was supported by renal biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 35-year-old woman presented to our hospital with decreased urine output and no past history of renal problems. Fifteen days prior to presentation, she had started treatment with intramuscular cefoperazone 1 g\/day for a scalp infection. On day 12 of therapy, the patient noted decreased urine output, anorexia, and weakness, but she continued taking cefoperazone for 3 more days. Hemodialysis and oral prednisolone 1 mg\/kg (30 mg twice daily) were started. Renal function returned to normal after 2 months of prednisolone treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Although AIN has been linked with other cephalosporins, as of June 18, 2004, to our knowledge, this is the first report of a cefoperazone-induced case. We based our diagnosis on the features of acute-onset renal failure, abnormal urinalysis findings, eosinophilia, inflammatory infiltrate in the interstitium, and recovery from renal failure after initiation of corticosteroid treatment. Application of the Naranjo probability scale indicated a probable relationship between the acute renal failure secondary to the possible AIN and cefoperazone therapy in this patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This case indicates that cefoperazone, like other cephalosporins, can cause AIN. We recommend close monitoring of renal function in patients who are prescribed this drug.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1e104","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T21:03:40Z","timestamp":1087938220000},"page":"1446-1448","source":"Crossref","is-referenced-by-count":7,"title":["Acute Interstitial Nephritis Due to Cefoperazone"],"prefix":"10.1177","volume":"38","author":[{"given":"Dilek","family":"Torun","sequence":"first","affiliation":[{"name":"Dilek Torun MD, Nephrologist, Faculty of Medicine, Baskent University, Adana Teaching and Medical Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siren","family":"Sezer","sequence":"additional","affiliation":[{"name":"Siren Sezer MD, Associate Professor of Nephrology, Faculty of Medicine, Baskent University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazilet","family":"Kayaselcuk","sequence":"additional","affiliation":[{"name":"Fazilet Kayaselcuk MD, Assistant Professor of Pathology, Faculty of Medicine, Baskent University, Adana Teaching and Medical Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysegul","family":"Zumrutdal","sequence":"additional","affiliation":[{"name":"Aysegul Zumrutdal MD, Fellow of Nephrology, Faculty of Medicine, Baskent University, Adana Teaching and Medical Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma N","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Fatma N Ozdemir MD, Professor of Nephrology, Faculty of Medicine, Baskent University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Haberal","sequence":"additional","affiliation":[{"name":"Mehmet Haberal MD FACS, Professor of General Surgery, Faculty of Medicine, Baskent University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"bibr1-aph.1E104","first-page":"62","volume-title":"Comprehensive clinical nephrology","author":"Rossert JJ","year":"2000","edition":"1"},{"key":"bibr2-aph.1E104","doi-asserted-by":"publisher","DOI":"10.3109\/08860229309065575"},{"key":"bibr3-aph.1E104","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-5-735"},{"key":"bibr4-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340120165045"},{"key":"bibr5-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1159\/000189178"},{"key":"bibr6-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-100100869"},{"key":"bibr7-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1159\/000188884"},{"key":"bibr8-aph.1E104","first-page":"1034","volume-title":"Textbook of nephrology","author":"Eknoyan G","year":"1995","edition":"3"},{"key":"bibr9-aph.1E104","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-7_Part_1-199310010-00027"},{"key":"bibr10-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(80)80023-4"},{"key":"bibr11-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90793-3"},{"key":"bibr12-aph.1E104","first-page":"194","volume":"206","author":"Pusey CD","year":"1983","journal-title":"QJ Med"},{"key":"bibr13-aph.1E104","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1E104","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:53Z","timestamp":1777374533000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1E104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1345\/aph.1E104"],"URL":"https:\/\/doi.org\/10.1345\/aph.1e104","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}