{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:38Z","timestamp":1777418858019,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To review the available literature addressing the role of low-molecular-weight heparin (LMWH) as an alternative to unfractionated heparin (UFH) in percutaneous coronary intervention (PCI) for treatment of non\u2013ST-elevation acute coronary syndromes (NSTEACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES<\/jats:title>\n                    <jats:p>A MEDLINE search (1966\u2013March 2004) identified pertinent articles using the key words acute coronary syndromes, unstable angina, non\u2013ST-elevation myocardial infarction, low-molecular-weight heparin, enoxaparin, dalteparin, glycoprotein IIb\/IIIa receptor antagonists, abciximab, tirofiban, eptifibatide, percutaneous transluminal coronary angioplasty, and percutaneous coronary intervention. The references of these articles were reviewed for additional pertinent references.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY SELECTION AND DATA EXTRACTION<\/jats:title>\n                    <jats:p>All human trials of LMWH in PCI for treatment of NSTEACS were evaluated. All pertinent studies were included in the review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS<\/jats:title>\n                    <jats:p>Administration of LMWH with or without a glycoprotein IIb\/IIIa inhibitor during PCI appears to be similar to UFH in terms of efficacy. LMWH, especially in combination with a glycoprotein IIb\/IIIa inhibitor, may increase risk of bleeding compared with UFH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Available clinical trials do not provide definitive evidence to suggest superiority of LMWH over UFH when managing NSTEACS during PCI; however, dosing strategies are available if an LMWH is to be used in this setting. THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT ACPE UNIVERSAL PROGRAM NUMBER: 407-000-04-038-H01<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1e176","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T21:48:51Z","timestamp":1100036931000},"page":"2094-2104","source":"Crossref","is-referenced-by-count":3,"title":["Role of Low-Molecular-Weight Heparin in Invasive Management of Non\u2013ST-Elevation Acute Coronary Syndromes"],"prefix":"10.1177","volume":"38","author":[{"given":"Lynette R","family":"Moser","sequence":"first","affiliation":[{"name":"Lynette R Moser PharmD, Assistant Clinical Professor, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University; Clinical Pharmacy Specialist, Department of Pharmacy Services, St. Johns Hospital and Medical Center, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S","family":"Kalus","sequence":"additional","affiliation":[{"name":"James S Kalus PharmD BCPS, Assistant Professor, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University; Clinical Pharmacy Specialist, Department of Pharmacy Services, Henry Ford Hospital, Detroit"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"bibr1-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001133420207"},{"key":"bibr2-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.1.61"},{"key":"bibr3-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)80001-W"},{"key":"bibr4-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1879"},{"key":"bibr5-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708143370702"},{"key":"bibr6-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1593"},{"key":"bibr7-aph.1E176","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00179-0"},{"key":"bibr8-aph.1E176","unstructured":"8. 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