{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:42:13Z","timestamp":1788370933029,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To review the available literature evaluating the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of etoricoxib, a highly selective cyclooxygenase-2 (COX-2) inhibitor that is not currently approved for use in the US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>Literature retrieval was accessed through MEDLINE (1966\u2013December 2004), Current Contents (1998\u2013December 2004), and Cochrane Library (4th quarter 2004). References from retrieved articles, information from the manufacturer, and abstracts from the American College of Rheumatology and Annual European Congress of Rheumatology meetings were searched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY SELECTION AND DATA EXTRACTION:<\/jats:title>\n                    <jats:p>All clinical trials published in English evaluating etoricoxib were included in this review. An abstract was excluded if it presented preliminary data from trials that are now published, analyzed data previously reported in a published clinical trial, or compared etoricoxib with placebo for an indication with published active-comparator controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Twelve clinical trials evaluating efficacy were reviewed. Efficacy for acute pain has been evaluated in acute gout, primary dysmenorrhea, and dental surgery and for chronic pain in rheumatoid arthritis, osteoarthritis, and chronic lower back pain. For safety, 3 clinical trials and 6 retrospective analyses of gastrointestinal, renovascular, or cardiovascular adverse effects were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Available studies demonstrate the efficacy of etoricoxib compared with nonsteroidal antiinflammatory drugs, but no published studies to date have compared etoricoxib with other selective COX-2 inhibitors. While these agents have demonstrated a significant reduction in gastrointestinal adverse effects, the cardiovascular adverse effects of selective COX-2 inhibition are not well defined. Further study is necessary to delineate the benefits and risks of etoricoxib compared with alternative treatment regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1e543","type":"journal-article","created":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T01:04:51Z","timestamp":1113354291000},"page":"854-862","source":"Crossref","is-referenced-by-count":54,"title":["Etoricoxib: A Highly Selective COX-2 Inhibitor"],"prefix":"10.1177","volume":"39","author":[{"given":"Shaunta\u2018 D","family":"Martina","sequence":"first","affiliation":[{"name":"Shaunta' D Martina PharmD, Pharmacy Practice Resident, College of Pharmacy, University of Oklahoma, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimi S","family":"Vesta","sequence":"additional","affiliation":[{"name":"Kimi S Vesta PharmD, Assistant Professor, College of Pharmacy, University of Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni L","family":"Ripley","sequence":"additional","affiliation":[{"name":"Toni L Ripley PharmD BCPS, Assistant Professor, College of Pharmacy, University of Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"bibr1-aph.1E543","first-page":"265","volume":"4","author":"Patrignani P","year":"2003","journal-title":"Exper Opin Pharmacother"},{"key":"bibr2-aph.1E543","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262180-00006"},{"key":"bibr3-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1080\/03009740310004766"},{"key":"bibr4-aph.1E543","first-page":"558","volume":"296","author":"Riendeau D","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr5-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.7.913"},{"key":"bibr6-aph.1E543","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453108"},{"key":"bibr7-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13271"},{"key":"bibr8-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003251122"},{"key":"bibr9-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.2.224"},{"key":"bibr10-aph.1E543","first-page":"813","volume":"29","author":"Kassahun K","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"bibr11-aph.1E543","volume-title":"Package insert. Arcoxia (etoricoxib)"},{"key":"bibr12-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003257219"},{"key":"bibr13-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003260338"},{"key":"bibr14-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7352.1488"},{"key":"bibr15-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1002\/art.20007"},{"key":"bibr16-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1159\/000072735"},{"key":"bibr17-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200405000-00004"},{"key":"bibr18-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90067-7"},{"key":"bibr19-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000133141.75831.57"},{"key":"bibr20-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-3-10"},{"key":"bibr21-aph.1E543","first-page":"1623","volume":"29","author":"Matsumoto AK","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr22-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.9.1052"},{"key":"bibr23-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125000282"},{"key":"bibr24-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-5900(03)00633-3"},{"key":"bibr25-aph.1E543","first-page":"7","volume":"61","author":"Geba GP","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"bibr26-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01407.x"},{"key":"bibr27-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07598.x"},{"key":"bibr28-aph.1E543","first-page":"832","volume":"50","author":"Baraf HS","year":"2004","journal-title":"Arthitis Rheum"},{"key":"bibr29-aph.1E543","unstructured":"Curtis SP, Lee M, Ng J, Watson DJ, Bolognese J, Harper S. Fewer upper-GI perforations, ulcers and bleeds with etoricoxib than with nonselective cyclooxygenase inhibitors (abstract). Ann Rheum Dis 2002;(suppl): FRI0057."},{"key":"bibr30-aph.1E543","first-page":"66","volume":"48","author":"Watson DJ","year":"2003","journal-title":"Arthritis Rheum"},{"key":"bibr31-aph.1E543","first-page":"FRI0164","volume":"61","author":"Curtis SP","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"bibr32-aph.1E543","first-page":"FRI0091","volume":"61","author":"Curtis SP","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"bibr33-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90007-0"},{"key":"bibr34-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011233432103"},{"key":"bibr35-aph.1E543","volume-title":"Safety of Vioxx","year":"2004"},{"key":"bibr36-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127578.21885.3E"},{"key":"bibr37-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.10.1247"},{"key":"bibr38-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16894-3"},{"key":"bibr39-aph.1E543","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050330"},{"key":"bibr40-aph.1E543","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-3-200502010-00005"},{"key":"bibr41-aph.1E543","first-page":"1600","volume":"48","author":"Curtis SP","year":"2003","journal-title":"Arthritis Rheum"},{"key":"bibr42-aph.1E543","first-page":"9","volume":"63","year":"2001","journal-title":"Pink Sheet"},{"key":"bibr43-aph.1E543","first-page":"12","volume":"63","author":"FDC reports","year":"2001","journal-title":"Pink Sheet"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1E543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:10:12Z","timestamp":1777374612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1E543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1345\/aph.1E543"],"URL":"https:\/\/doi.org\/10.1345\/aph.1e543","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}