{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:37:36Z","timestamp":1777419456330,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The dietary supplement willow bark, also known simply as willow, contains salicylates that may present a safety risk to people. Current regulations do not require willow bark to include any cautions on its label.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate the absence or presence of label warnings related to salicylates contained in willow bark to ascertain whether a potentially dangerous lack of information exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The label of each willow supplement and willow-containing product was assessed for the presence or absence of 3 warnings: (1) aspirin allergy\/sensitivity, (2) use of anticoagulants or \u201cblood thinners,\u201d and (3) children with flu-like symptoms or Reye's syndrome. Products from pharmacies and health food stores were targeted and their labels analyzed. A compilation of the identified products was used to conduct a similar evaluation of warnings from their Web sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 58 willow bark\u2013containing and 12 single-ingredient willow bark products were assessed. Of the 70 products evaluated, only 8.6% listed a warning. The warning regarding aspirin sensitivity was present on 4.3%, Reye's syndrome was 2.9%, and interactions with anticoagulants\/\u201cblood thinners\u201d was 4.3%. One product was labeled as aspirin-free. Percentages were lower on Web sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>There is a dearth of information regarding potential safety risks on the labels of willow bark and willow bark\u2013containing products. Combination products containing willow bark may pose a greater danger to at-risk patients based on their sheer volume. Counseling of patients who take dietary supplements can improve the situation; however, it may ultimately take improved requirements for dietary supplement labeling to fully address this problem.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1e650","type":"journal-article","created":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T23:08:35Z","timestamp":1117580915000},"page":"1234-1237","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Presence of Aspirin-Related Warnings with Willow Bark"],"prefix":"10.1177","volume":"39","author":[{"given":"Kevin A","family":"Clauson","sequence":"first","affiliation":[{"name":"Kevin A Clauson PharmD, Assistant Professor, Pharmacy Practice; Drug Information Specialist, College of Pharmacy\u2014West Palm Beach Program, Nova Southeastern University, Palm Beach Gardens, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marile L","family":"Santamarina","sequence":"additional","affiliation":[{"name":"Marile L Santamarina, PharmD Student, College of Pharmacy\u2014West Palm Beach Program, Nova Southeastern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M","family":"Buettner","sequence":"additional","affiliation":[{"name":"Christian M Buettner, PharmD Student, College of Pharmacy\u2014West Palm Beach Program, Nova Southeastern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacintha S","family":"Cauffield","sequence":"additional","affiliation":[{"name":"Jacintha S Cauffield PharmD, Assistant Professor, Pharmaceutical Sciences; Academic Facilitator, College of Pharmacy\u2014West Palm Beach Program, Nova Southeastern University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"bibr1-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D027"},{"key":"bibr2-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1021\/jo001241s"},{"key":"bibr3-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00442-3"},{"key":"bibr4-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.12.1388"},{"key":"bibr5-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.981"},{"key":"bibr6-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1998.3806475.x"},{"key":"bibr7-aph.1E650","first-page":"1","volume":"27","author":"Barnes PM","year":"2004","journal-title":"Adv Data"},{"key":"bibr8-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2001)001<0122:CAAMUA>2.0.CO;2"},{"key":"bibr9-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2002)002<0099:UOCATA>2.0.CO;2"},{"key":"bibr10-aph.1E650","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1113-7"},{"key":"bibr11-aph.1E650","first-page":"18861","volume":"68","year":"2003","journal-title":"Fed Reg"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1E650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1E650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:10:31Z","timestamp":1777374631000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1E650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":11,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1345\/aph.1E650"],"URL":"https:\/\/doi.org\/10.1345\/aph.1e650","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}