{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:16:46Z","timestamp":1790543806174,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Nonadherence to medication may lead to poor medical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To describe medication-taking behavior of patients with a history of acute coronary syndromes (ACS) for 4 classes of drugs and determine the relationship between self-reported adherence and patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Consenting patients with the diagnosis of ACS were interviewed by telephone approximately 10 months after discharge. The survey elicited data characterizing the patient, current medication regimens, beliefs about drug therapy, reasons for discontinuing medications, and adherence. The survey included the Beliefs About Medicine Questionnaire providing 4 scales: Specific Necessity, Specific Concerns, General Harm, and General Overuse, and the Medication Adherence Scale (MAS). Multivariate regression was used to determine the independent variables with the strongest association to the MAS. A p value \u22640.05 was considered significant for all analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Two hundred eight patients were interviewed. Mean \u00b1 SD age was 64.9 \u00b1 13.0 years, with 60.6% male, 95.7% white, 57.3% with a college education, 87.9% living with \u22651 other person, and 42% indicating excellent or very good health. The percentage of patients continuing on medication at the time of the survey category ranged from 87.4% (aspirin) to 66.0% (angiotensin-converting enzyme inhibitors). Reasons for stopping medication included physician discontinuation or adverse effects. Of patients still on drug therapy, the mean MAS was 1.3 \u00b1 0.4, with 53.8% indicating nonadherence (score &gt;1). The final regression model showed R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.132 and included heart-related health status and Specific Necessity as significant predictor variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>After ACS, not all patients continue their drugs or take them exactly as prescribed. Determining beliefs about illness and medication may be helpful in developing interventions aimed at improving adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1g249","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T23:28:16Z","timestamp":1128468496000},"page":"1792-1797","source":"Crossref","is-referenced-by-count":70,"title":["Adherence to Medications by Patients After Acute Coronary Syndromes"],"prefix":"10.1177","volume":"39","author":[{"given":"Anchal","family":"Sud","sequence":"first","affiliation":[{"name":"Anchal Sud BS, Medical Student, College of Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M","family":"Kline-Rogers","sequence":"additional","affiliation":[{"name":"Eva M Kline-Rogers MS RN, Cardiology Research Nurse, Division of Cardiology, University of Michigan Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A","family":"Eagle","sequence":"additional","affiliation":[{"name":"Kim A Eagle MD, Professor, Division of Cardiology, University of Michigan Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Fang","sequence":"additional","affiliation":[{"name":"Jianming Fang PhD, Statistician, Division of Cardiology, University of Michigan Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Armstrong","sequence":"additional","affiliation":[{"name":"David F Armstrong MD, General Internal Medicine Resident, Division of Cardiology, University of Michigan Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Krishna Rangarajan MD, Undergraduate Research Student, Division of Cardiology, University of Michigan Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F","family":"Otten","sequence":"additional","affiliation":[{"name":"Richard F Otten MD, General Internal Medicine Resident, Division of Cardiology, University of Michigan Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana R","family":"Stafkey-Mailey","sequence":"additional","affiliation":[{"name":"Dana R Stafkey-Mailey PharmD, PhD Candidate, at time of the study, Pharmacoeconomics Fellow, Division of Cardiology, University of Michigan Health System and Pfizer, Inc.; now, Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie D","family":"Taylor","sequence":"additional","affiliation":[{"name":"Stephanie D Taylor PhD, Assistant Professor, College of Pharmacy, University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Erickson","sequence":"additional","affiliation":[{"name":"Steven R Erickson PharmD, Associate Professor, College of Pharmacy, University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"bibr1-aph.1G249","volume-title":"Heart disease and stroke statistics\u20142004 update","author":"American Heart Association","year":"2003"},{"key":"bibr2-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.10.1269"},{"key":"bibr3-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.4.462"},{"key":"bibr4-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(99)00014-8"},{"key":"bibr5-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1097\/00005082-200307000-00006"},{"key":"bibr6-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510060088038"},{"key":"bibr7-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320370021023"},{"issue":"9","key":"bibr8-aph.1G249","first-page":"S5","volume":"27","author":"Berg JS","year":"1993","journal-title":"Ann Pharmacother"},{"key":"bibr9-aph.1G249","first-page":"155","volume-title":"Perceptions of health and illness: current research and applications","author":"Horne R","year":"1997"},{"key":"bibr10-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1080\/08870440290001502"},{"key":"bibr11-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1016\/0738-3991(87)90093-0"},{"key":"bibr12-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1080\/08870449908407311"},{"key":"bibr13-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198601000-00007"},{"key":"bibr14-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7404.1419"},{"key":"bibr15-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/57.2.139"},{"key":"bibr16-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7000.293"},{"key":"bibr17-aph.1G249","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1097\/00004872-199715033-00006","volume":"15","author":"Caro JJ","year":"1997","journal-title":"J Hypertens"},{"key":"bibr18-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2003.143"},{"key":"bibr19-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321703"},{"key":"bibr20-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199909000-00002"},{"key":"bibr21-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00363.x"},{"key":"bibr22-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892289"},{"key":"bibr23-aph.1G249","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01699-0"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1345\/aph.1G249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:09:24Z","timestamp":1777374564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1G249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1345\/aph.1G249"],"URL":"https:\/\/doi.org\/10.1345\/aph.1g249","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}