{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:47:22Z","timestamp":1777420042364,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report a case of an acute dystonic episode in a patient with Tourette's disorder (TD) treated with the partial dopamine agonist aripiprazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary:<\/jats:title>\n                    <jats:p>An 18-year-old male with TD was prescribed aripiprazole 10 mg orally daily, which produced a significant improvement in his symptoms. However, after 3 days of treatment, he experienced an acute episode of dystonia with facial muscle spasm, oculogyric crisis, and torticolis. All symptoms resolved after a single intramuscular injection of Dipendine 5 mg. The Naranjo probability scale indicated that the adverse events were probably caused by aripiprazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>To our knowledge, as of this writing, this is the first report concerning an aripiprazole-induced dystonic episode in an adult, and it is especially notable because it occurred at low dosage. Aripiprazole is a dopamine partial agonist and a serotonin2A antagonist with a favorable adverse effect profile. Short-term clinical trials reported a very low incidence of extrapyramidal symptoms, with akathisia being the most common, although there have been reports of severe extrapyramidal symptoms in a 3-year-old child and in an adolescent with a previous history of such symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Acute dystonic phenomena may be caused by aripiprazole, although the drug's suggested mode of action largely precludes them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1g331","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T23:48:16Z","timestamp":1143589696000},"page":"775-777","source":"Crossref","is-referenced-by-count":46,"title":["Acute Dystonia with Low-Dosage Aripiprazole in Tourette's Disorder"],"prefix":"10.1177","volume":"40","author":[{"given":"Konstantinos N","family":"Fountoulakis","sequence":"first","affiliation":[{"name":"Laboratory of Psychophysiology, Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Siamouli","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry, Aristotle University of Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotiris","family":"Kantartzis","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry, Aristotle University of Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Panagiotidis","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry, Aristotle University of Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolos","family":"lacovides","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry, Aristotle University of Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George St","family":"Kaprinis","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry, Aristotle University of Thessaloniki"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"bibr1-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820210068008"},{"key":"bibr2-aph.1G331","volume-title":"Diagnostic and statistical manual of mental disorders","year":"1994","edition":"4"},{"key":"bibr3-aph.1G331","volume-title":"The ICD-10 classification of mental and behavioural disorders\u2014diagnostic criteria for research","year":"1993"},{"key":"bibr4-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.1.14"},{"key":"bibr5-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199901000-00024"},{"key":"bibr6-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.8.1057"},{"key":"bibr7-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D497"},{"key":"bibr8-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.625"},{"key":"bibr9-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005365"},{"key":"bibr10-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000150229.69124.66"},{"key":"bibr11-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"bibr12-aph.1G331","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216110-00008"},{"key":"bibr13-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr14-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1268"},{"key":"bibr15-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000095540.18151.b0"},{"key":"bibr16-aph.1G331","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418040-00005"},{"key":"bibr17-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C297"},{"key":"bibr18-aph.1G331","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.10.974"},{"key":"bibr19-aph.1G331","volume-title":"Schizophrenia: somatic treatment. 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