{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:47:24Z","timestamp":1777420044325,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,4]]},"abstract":"\n Objective:<\/jats:title>\n To report on a patient developing hepatic veno-occlusive disease while being treated with immunosuppressive doses of cyclophosphamide (\u22642 mg\/kg).<\/jats:p>\n <\/jats:sec>\n \n Case Summary:<\/jats:title>\n A 66-year-old woman with autoimmune hemolytic anemia developed hepatic veno-occlusive disease while being treated with immunosuppressive cyclophosphamide 100 mg\/day in combination with roxithromycin (total dose 600 mg\/day). After all drugs were stopped, the patient recovered within 2 weeks. The Naranjo probability scale indicated a probable relationship between veno-occlusive disease and treatment with cyclophosphamide in this patient.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Since roxithromycin inhibits CYP3A4, which is involved with cyclophosphamide metabolism, a drug-drug interaction could have been responsible. In addition, roxithromycin is an inhibitor of the drug transporter P-glycoprotein, possibly leading to accumulation of cyclophosphamide in endothelial cells. Alternatively, since cyclophosphamide has been reported to induce apoptosis, roxithromycin could have rendered endothelial cells more vulnerable for apoptosis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n In specific patients, cyclophosphamide can be associated with hepatic veno-occlusive disease at immunosuppressive doses.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1g441","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T20:39:39Z","timestamp":1141677579000},"page":"767-770","source":"Crossref","is-referenced-by-count":9,"title":["Hepatic Veno-Occlusive Disease Associated with Immunosuppressive Cyclophosphamide Dosing and Roxithromycin"],"prefix":"10.1177","volume":"40","author":[{"given":"Johannes","family":"Beltinger","sequence":"first","affiliation":[{"name":"Gastroenterology, Division of Gastroenterology, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Haschke","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology & Toxicology, University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priska","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Department of Research, University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Michot","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Terracciano","sequence":"additional","affiliation":[{"name":"Molecular Pathology, Department of Pathology, University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Kr\u00e4henb\u00fchl","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology & Toxicology, University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"bibr1-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704285"},{"key":"bibr2-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch095"},{"key":"bibr3-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr4-aph.1G441","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161040-00003"},{"key":"bibr5-aph.1G441","first-page":"1053","volume":"26","author":"Yamazaki H","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"bibr6-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050201"},{"key":"bibr7-aph.1G441","first-page":"11","volume":"13","author":"Blomgren H","year":"1991","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"bibr8-aph.1G441","doi-asserted-by":"publisher","DOI":"10.2174\/1389200043489090"},{"key":"bibr9-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1080\/00498250110060969"},{"key":"bibr10-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1021\/js970290q"},{"key":"bibr11-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(94)90097-3"},{"key":"bibr12-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3126"},{"key":"bibr13-aph.1G441","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.10.1541"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:12:19Z","timestamp":1777374739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1G441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1345\/aph.1G441"],"URL":"https:\/\/doi.org\/10.1345\/aph.1g441","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}