{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:47:31Z","timestamp":1777420051330,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the immunogenicity, efficacy, safety, and new recommendations for routine use of the tetravalent meningococcal conjugate vaccine (MCV4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A MEDLINE search (1966\u2013June 2005) was conducted using the key words Neisseria meningitidis and meningococcal vaccines for clinical trials limited to human research published in the English language.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>Randomized, controlled, multicenter trials were reviewed and included to evaluate the safety and efficacy of MCV4. Additional open-label trials on the use of MCV4 in children less than 24 months of age are included since these studies may be used to support the approval of the vaccine for use in children. Literature on epidemiology and pathology of meningococcal meningitis and the Advisory Committee on Immunization Practices (ACIP) recommendations were also reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>MCV4 is approved for active immunization of adolescents and adults between the ages of 11 and 55 years for the prevention of disease caused by N. meningitidis serogroups A, C, Y, and W-135. MCV4 has been shown to have comparable immunogenicity and a similar adverse reaction profile to the tetravalent meningococcal polysaccharide vaccine (MPSV4). It is expected that MCV4 will provide a longer duration of protection from meningococcal disease than MPSV4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Based on published immunogenicity, efficacy, and safety data, as well as the recent recommendations by the ACIP for its routine use, MCV4 is the preferred meningococcal vaccine for persons between 11 and 55 years of age and should be included on pharmacy formularies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1g486","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T20:39:39Z","timestamp":1141677579000},"page":"666-673","source":"Crossref","is-referenced-by-count":4,"title":["Update on Prevention of Meningococcal Disease: Focus on Tetravalent Meningococcal Conjugate Vaccine"],"prefix":"10.1177","volume":"40","author":[{"given":"Allana J","family":"Mehlhorn","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Administration, Lloyd L Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly E","family":"Balcer","sequence":"additional","affiliation":[{"name":"Lloyd L Gregory School of Pharmacy, Palm Beach Atlantic University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon J","family":"Sucher","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Administration, Lloyd L Gregory School of Pharmacy, Palm Beach Atlantic University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"bibr1-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441807"},{"issue":"7","key":"bibr2-aph.1G486","first-page":"1","volume":"54","journal-title":"MMWR Motb Mortal Wkly Rep"},{"key":"bibr3-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000154438.37306.ab"},{"key":"bibr4-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb035678"},{"key":"bibr5-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-4-29"},{"key":"bibr6-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199611000-00009"},{"key":"bibr7-aph.1G486","unstructured":"Meningococcal disease and meningococcal vaccines, April 2005. Centers for Disease Control and Prevention, www.cdc.gov\/nip\/vaccine\/mening\/mening_fs.pdf (accessed 2005 Aug 1)."},{"key":"bibr8-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.55.091902.103612"},{"key":"bibr9-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.1.271"},{"key":"bibr10-aph.1G486","first-page":"97","volume":"50","year":"2001","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr11-aph.1G486","unstructured":"Product approval information\u2014licensing action. Food and Drug Administration, Centers for Biologies Evaluation and Research, www.fda.gov\/cber\/products\/mpdtave011405.htm (accessed 2005 Aug 1)."},{"key":"bibr12-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.12.1433"},{"key":"bibr13-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.8.3.616-623.2001"},{"key":"bibr14-aph.1G486","unstructured":"Vaccines and related biological products advisory committee briefing information for tetravalent meningococcal conjugate vaccine. Food and Drug Administration Centers for Biologies Evaluation and Research. www.fda.gov\/ohrms\/dockets\/ac\/04\/briefing\/2004-4072bl.htm (accessed 2005 Aug 1)."},{"key":"bibr15-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00591-1"},{"key":"bibr16-aph.1G486","volume-title":"Menactra (meningococcal [groups A, C, Y, and W-135] polysaccharide diphtheria toxoid conjugate vaccine)","author":"Package insert.","year":"2005"},{"key":"bibr17-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000126297.28952.f8"},{"key":"bibr18-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200210000-00019"},{"key":"bibr19-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000148928.10057.86"},{"key":"bibr20-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1086\/345763"},{"key":"bibr21-aph.1G486","first-page":"1","volume":"54","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr22-aph.1G486","unstructured":"Guillain\u2013Barr\u00e9 syndrome among adolescents who received meningococcal conjugate vaccine, December 2005. Centers for Disease Control and Prevention, www.cdc.gov\/nip\/vacsafe\/concerns\/gbs\/gbs-menactra-facts.pdf (accessed 2006 Feb 17)."},{"key":"bibr23-aph.1G486","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00061-0"},{"key":"bibr24-aph.1G486","author":"Shepard C","year":"2004","journal-title":"Final program and abstracts, 42nd Annual Meeting of Infectious Diseases Society of America"},{"key":"bibr25-aph.1G486","unstructured":"ACIP recommends adolescent vaccination for tetanus, diphtheria and pertussis vaccine. National Immunization Program Press Release. www.cdc.gov\/nip\/pr\/pr_tdap_jun2005.htm (accessed 2005 Aug 7)."}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:12:21Z","timestamp":1777374741000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1G486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1345\/aph.1G486"],"URL":"https:\/\/doi.org\/10.1345\/aph.1g486","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}