{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:32Z","timestamp":1787166812290,"version":"build-2736575974"},"reference-count":62,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the pharmacology, pharmacokinetics, effectiveness, safety, and therapeutic considerations related to the use of doxercalciferol in the treatment of secondary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>A MEDLINE search (1966\u2013June 2006) was conducted using the key words vitamin D, ergocalciferols, and secondary hyperparathyroidism. Text word searches were also performed for the terms 1-\u03ac-hydroxy-vitamin D2,1-\u03ac-hydroxyergocalciferol, Hectorol, and doxercalciferol. Searches were limited to studies published in English and conducted in human subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction:<\/jats:title>\n                    <jats:p>All published clinical studies evaluating the safety and effectiveness of doxercalciferol in secondary hyperparathyroidism were reviewed, and anecdotal patient reports were also evaluated. Selected clinical studies involving the use of calcitriol and\/or paricalcitol in the treatment of secondary hyperparathyroidism were also included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Doxercalciferol effectively reduces parathyroid hormone levels in patients with chronic kidney disease (CKD). Both oral and intravenous administration can significantly increase serum calcium and\/or phosphorus levels as evidenced by placebo-controlled clinical trials. This agent has not been studied comparatively with calcitriol or paricalcitol to assess relative safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Doxercalciferol is approved for and effective in the treatment of secondary hyperparathyroidism related to CKD, both before and during dialysis, but has not demonstrated a lower incidence of hypercalcemia and\/or hyperphosphatemia in relation to other vitamin D therapies. The drug is available in both oral and intravenous dosage forms. Doxercalciferol should be maintained as a formulary alternative for patients unresponsive to or intolerant of other vitamin D therapies, but comparative randomized studies are needed to differentiate its place in therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1g523","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T23:10:53Z","timestamp":1161731453000},"page":"1955-1965","source":"Crossref","is-referenced-by-count":16,"title":["Formulary Forum Doxercalciferol Treatment of Secondary Hyperparathyroidism"],"prefix":"10.1177","volume":"40","author":[{"given":"Vincent C","family":"Dennis","sequence":"first","affiliation":[{"name":"Department of Pharmacy Clinical and Administrative Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK; Clinical Pharmacy Specialist, University of Oklahoma Family Medicine Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy L","family":"Albertson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Clinical and Administrative Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"bibr1-aph.1G523","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2005.18408.x"},{"key":"bibr2-aph.1G523","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.64"},{"key":"bibr3-aph.1G523","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2005.18404.x"},{"key":"bibr4-aph.1G523","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9531176"},{"key":"bibr5-aph.1G523","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102131"},{"key":"bibr6-aph.1G523","first-page":"695","volume":"39","author":"Raggi P","year":"2002","journal-title":"A link between end-stage renal disease and cardiovascular disease? 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