{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:25:13Z","timestamp":1783981513648,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe a case of a delayed-type hypersensitivity (DTH) reaction to piperacillin\/tazobactam in which painful paresthesiae were a predominant feature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary:<\/jats:title>\n                    <jats:p>\n                      A 27-year-old man with a history of intravenous drug abuse was admitted for treatment of a pulmonary parenchymal abscess in the setting of lower-limb deep-venous thrombosis and methicillin-sensitive Staphylococcus aureus bacteremia. He was treated with intravenous piperacillin\/tazobactam 4.5 g 3 times daily; however, after 2 weeks of therapy, he developed symptoms (eg, fever, chills) and laboratory abnormalities (eg, white blood cell count 2.1 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      \/mm\n                      <jats:sup>3<\/jats:sup>\n                      , erythrocyte sedimentation rate 63 mm\/h) suggestive of a DTH reaction. This was accompanied by infusion-related painful paresthesiae. The symptoms and laboratory abnormalities resolved within 48 hours of treatment being switched to flucloxacillin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Due to the close temporal association and the absence of any other obvious explanation, we believe these paresthesiae represent an additional feature of the DTH reaction to piperacillin\/tazobactam in this patient. Use of the Naranjo probability scale indicated a probable relationship between the paresthesiae and administration of piperacillin\/tazobactam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>To our knowledge, as of March 24, 2006, this is the first case in which a DTH reaction to piperacillin\/tazobactam manifesting as fever, neutropenia, and thrombocytopenia has been associated with paresthesiae.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1g526","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T21:46:20Z","timestamp":1145396780000},"page":"977-979","source":"Crossref","is-referenced-by-count":10,"title":["Piperacillin\/Tazobactam\u2013Induced Paresthesiae"],"prefix":"10.1177","volume":"40","author":[{"given":"Jonathan","family":"Lambourne","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Genitourinary Medicine, St James's Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Genitourinary Medicine, St James's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Hughes","sequence":"additional","affiliation":[{"name":"National Medicines Information Centre, St James's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepta","family":"Merry","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Genitourinary Medicine, St James's 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