{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:23:20Z","timestamp":1777418600047,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe a case of atenolol-induced breast pain and swelling in a patient receiving atenolol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary:<\/jats:title>\n                    <jats:p>A 54-year-old woman was diagnosed with hypertension with no existing comorbidity. The patient was not taking any prescription medications, but was using an herbal supplement and several other over-the-counter supplements. After diet and exercise failed to control the woman's blood pressure, atenolol 25 mg daily was initiated. She reported symptoms of insomnia 9 days after starting the medication. During a follow-up visit 5 weeks later, the patient reported continued insomnia, as well as a 6 day history of breast pain, swelling, and tenderness. Atenolol was quickly titrated to discontinuation, and a thiazide diuretic was prescribed. Subsequently, the pain and swelling gradually resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Assessment using the Naranjo probability scale revealed that the adverse reaction was probably associated with atenolol. While rare cases of hyperprolactinemia and galactorrhea have been reported with \u03b2-blocker use, no reports of breast pain caused by this drug class were identified in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Atenolol has many reported adverse reactions, both common and rare; however, until this report, breast pain and swelling had not been documented adverse reactions. Clinicians should be aware that atenolol may be a cause of nonorganic breast pain and swelling in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1g528","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T20:24:58Z","timestamp":1144182298000},"page":"990-992","source":"Crossref","is-referenced-by-count":3,"title":["Atenolol-Induced Breast Pain in a Woman with Hypertension"],"prefix":"10.1177","volume":"40","author":[{"given":"Julia A","family":"Kelleher","sequence":"first","affiliation":[{"name":"Kaiser Foundation Health Plan of Colorado, 280 Exempla Circle, Lafayette, CO 80026"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"bibr1-aph.1G528","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"bibr2-aph.1G528","volume-title":"Package insert. Atenolol","year":"2002"},{"key":"bibr3-aph.1G528","unstructured":"AHFS drug information. February 2004. Atenolol. http:\/\/online.statref.com\/document.aspx?fxid=1&docid=469 (accessed 2004 Apr 6)."},{"key":"bibr4-aph.1G528","volume-title":"DRUGDEX System"},{"key":"bibr5-aph.1G528","unstructured":"Drug facts and comparisons. St. Louis: Facts and Comparisons, 468\u20139."},{"key":"bibr6-aph.1G528","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1982.tb03178.x"},{"key":"bibr7-aph.1G528","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90470-7"},{"key":"bibr8-aph.1G528","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-522_1"},{"key":"bibr9-aph.1G528","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr10-aph.1G528","unstructured":"Jellin JM, Gregory PJ, Batz F.,  Soy. Pharmacist's letter\/prescriber's letter. Natural Medicines Comprehensive Database. www.naturaldatabase.com (accessed 2004 Aug 18)."},{"key":"bibr11-aph.1G528","volume-title":"AltMedDex Points System","author":"Grasberger F","year":"2004"},{"key":"bibr12-aph.1G528","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(98)80010-4"},{"key":"bibr13-aph.1G528","doi-asserted-by":"publisher","DOI":"10.1054\/brst.1999.0149"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1G528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:42Z","timestamp":1777374462000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1G528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1345\/aph.1G528"],"URL":"https:\/\/doi.org\/10.1345\/aph.1g528","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}