{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:41:57Z","timestamp":1777419717308,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2006,10]]},"abstract":"\n Objective:<\/jats:title>\n To report a case of palmar\u2013plantar hyperhidrosis (PPH) In which paroxetine was found to be helpful.<\/jats:p>\n <\/jats:sec>\n \n Case Summary:<\/jats:title>\n A 32-year-old man with a history of excessive sweating of the palms and soles since childhood was diagnosed with PPH and was prescribed paroxetine 10 mg\/day, which was increased to 20 mg\/day. After one month, he experienced a marked reduction in sweating and improvement in socio-occupational functioning, which were sustained during follow-up at 6 months without any emergent adverse effects.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Paroxetine's anticholinergic action may be responsible for its beneficial effect in PPH, as it may override the adrenergic mechanism, which has a minor effect on sweating from eccrine glands. Alternatively, paroxetine's beneficial effect in PPH may be secondary to its antianxiety effect, through central mechanisms.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Paroxetine may be a useful option in the treatment of PPH.<\/jats:p>\n <\/jats:sec>","DOI":"10.1345\/aph.1h208","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T04:28:24Z","timestamp":1156912104000},"page":"1884-1886","source":"Crossref","is-referenced-by-count":23,"title":["Paroxetine Useful for Palmar\u2013Plantar Hyperhidrosis"],"prefix":"10.1177","volume":"40","author":[{"given":"Samir Kumar","family":"Praharaj","sequence":"first","affiliation":[{"name":"Central Institute of Psychiatry, Ranchi, Jharkhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manu","family":"Arora","sequence":"additional","affiliation":[{"name":"Central Institute of Psychiatry"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"bibr1-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70081-5"},{"key":"bibr2-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-003-0107-5"},{"key":"bibr3-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62679-5"},{"key":"bibr4-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817724"},{"key":"bibr5-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197707000-00006"},{"key":"bibr6-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"bibr7-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(99)00111-1"},{"key":"bibr8-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70062-0"},{"key":"bibr9-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb01601.x"},{"key":"bibr10-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1159\/000248810"},{"key":"bibr11-aph.1H208","first-page":"1","volume":"8","author":"Lauchli S","year":"2003","journal-title":"Skin Therapy Lett"},{"key":"bibr12-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70063-3"},{"key":"bibr13-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70532-8"},{"key":"bibr14-aph.1H208","doi-asserted-by":"publisher","DOI":"10.4065\/80.5.657"},{"key":"bibr15-aph.1H208","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2000","edition":"4"},{"key":"bibr16-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(02)00297-X"},{"key":"bibr17-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v10.i3-4.70"},{"key":"bibr18-aph.1H208","first-page":"27","volume":"580","author":"Telaranta T.","year":"1998","journal-title":"Eur J Surg"},{"key":"bibr19-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.2.120"},{"key":"bibr20-aph.1H208","first-page":"61","volume":"53","author":"Boyer WF","year":"1992","journal-title":"J Clin Psychiatry"},{"key":"bibr21-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2001.tb00189.x"},{"key":"bibr22-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/61.3.287"},{"key":"bibr23-aph.1H208","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n0402"},{"key":"bibr24-aph.1H208","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E564"},{"key":"bibr25-aph.1H208","doi-asserted-by":"publisher","DOI":"10.4065\/78.2.167"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1H208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.1H208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:11:32Z","timestamp":1777374692000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.1H208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1345\/aph.1H208"],"URL":"https:\/\/doi.org\/10.1345\/aph.1h208","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}