{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:26Z","timestamp":1777418846350,"version":"3.51.4"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review the literature on the prevention of postoperative nausea and vomiting (PONV) in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>Literature retrieval was accessed through MEDLINE (1966\u2013December 2006) using the terms postoperative nausea and vomiting, prevention and treatment. Article references were hand-searched for additional relevant articles and abstracts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection And Data Extraction:<\/jats:title>\n                    <jats:p>All studies published in English were evaluated. Those dealing with prevention and treatment of PONV in adults were included in the review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>\n                      Evidence suggests that providing prophylactic antiemetic medications in high-risk surgical patients is warranted. 5-HT\n                      <jats:sub>3<\/jats:sub>\n                      receptor antagonists are widely used, with no one agent being clearly superior. However, studies have shown other types of agents to ho more cost-effective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The first step in the prevention of PONV is assessment and reduction of risk factors. Although nonpharmacologic therapies may play a role in the treatment of PONV, the mainstay of therapy for PONV is pharmacologic modalities. Patients at moderate to high risk for PONV need prophylactic antiemetic therapy. High-risk patients may require combination therapy with 2 or 3 agents from different antiemetic classes. Rescue antiemetic therapy is needed by patients who actually develop PONV. The agents of choice in such cases should be from antiemetic classes different from those used for prophylaxis of PONV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.1h398","type":"journal-article","created":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T21:55:58Z","timestamp":1167774958000},"page":"68-78","source":"Crossref","is-referenced-by-count":35,"title":["Prevention of Postoperative Nausea and Vomiting"],"prefix":"10.1177","volume":"41","author":[{"given":"Sheila M","family":"Wilhelm","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Wayne State University, Detroit, Ml"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L","family":"Dehoorne-Smith","sequence":"additional","affiliation":[{"name":"Manager of Patient Care Services, St. John Hospital and Medical Center, Detroit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramodini B","family":"Kale-Pradhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Wayne State University, St. John Hospital and Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"bibr1-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000068580.00245.95"},{"key":"bibr2-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.10.1233"},{"key":"bibr3-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20516"},{"key":"bibr4-aph.1H398","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059020-00005"},{"key":"bibr5-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/56.8.729"},{"key":"bibr6-aph.1H398","first-page":"105-1","volume-title":"Applied therapeutics: the clinical use of drugs","author":"Koda-Kimble MA","year":"1995","edition":"6"},{"key":"bibr7-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"bibr8-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1994.tb03576.x"},{"key":"bibr9-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200301000-00011"},{"key":"bibr10-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2004.05.003"},{"key":"bibr11-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.3.379"},{"key":"bibr12-aph.1H398","first-page":"682","volume":"80","author":"Suntheralingham Y","year":"1995","journal-title":"Anesth Analg"},{"key":"bibr13-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199911000-00014"},{"key":"bibr14-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200101000-00022"},{"key":"bibr15-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199704000-00023"},{"key":"bibr16-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199906000-00031"},{"key":"bibr17-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200211000-00008"},{"key":"bibr18-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00018"},{"key":"bibr19-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013442"},{"key":"bibr20-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000055818.64084.41"},{"key":"bibr21-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2003.11.001"},{"key":"bibr22-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200205000-00013"},{"key":"bibr23-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.19.2124"},{"key":"bibr24-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(99)00103-8"},{"key":"bibr25-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2000.9283"},{"key":"bibr26-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(00)00297-3"},{"key":"bibr27-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.119249"},{"key":"bibr28-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.113032"},{"key":"bibr29-aph.1H398","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200207000-00024"},{"key":"bibr30-aph.1H398","volume-title":"DRUGDEX system. 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